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Harnessing the power of biomarkers for diffuse intrinsic pontine gliomas
Nature Medicine, Published online: 12 May 2026; doi:10.1038/s41591-026-04399-2The BIOMEDE trial, although negative for its primary endpoint, illustrates the utility of adaptive trial designs and biopsy-informed tumor profiling in guiding treatment decisions and patient counseling — and provides mechanistic evidence that…
Data-Driven Decision Support in Obesity Management Commission: enabling more equitable and personalized obesity care
Nature Medicine, Published online: 12 May 2026; doi:10.1038/s41591-026-04363-0Announced in this Comment and in collaboration with Nature Medicine is the convening of the Data-Driven Decision Support in Obesity Management Commission, to promote adequate scientific evidence to support obesity management across global…
CRISPR−Cas9 CD33-deleted allogeneic hematopoietic cell transplantation with gemtuzumab ozogamicin maintenance in AML: a phase 1/2 trial
Nature Medicine, Published online: 12 May 2026; doi:10.1038/s41591-026-04362-1In a first-in-human trial combining the transplantation of CD33-negative CRISPR-edited hematopoietic cells with the CD33-targeted antibody–drug conjugate gemtuzumab ozogamicin, all transplanted patients achieved primary engraftment, and the treatment was well tolerated.
Genomic epidemiology of the 2025 mpox epidemic in Sierra Leone
Nature Medicine, Published online: 12 May 2026; doi:10.1038/s41591-026-04385-8A phylogenetic analysis examined the origins of the first mpox outbreak in Sierra Leone and found evidence of an emerging lineage (G.1) that has likely descended from the Nigerian epidemic and emerged in…
Individual differences in prosocial learning are represented in the hippocampal dorsal CA1
Nature Neuroscience, Published online: 12 May 2026; doi:10.1038/s41593-026-02292-2La Greca and colleagues show that by witnessing a conspecific’s actions, mice learn how actions can lead to shared food, forming flexible social action–outcome associations that require dorsal CA1 and bias future prosocial…
Optics-free spatial genomics for mapping mammalian brain aging by IRISeq
Nature Neuroscience, Published online: 12 May 2026; doi:10.1038/s41593-026-02293-1The authors developed an optics-free spatial genomics method to map mouse brain aging, revealing region-specific inflammation and showing that lymphocytes promote harmful interferon signaling, whereas their loss preserves ependymal cells and reshapes glial…
STAT+: Capsida says it still doesn’t know what caused gene therapy death
Some in the gene therapy field lament lost time while Capsida kept silent about the brain receptor it was targeting when things went wrong.
STAT+: In the battle of sepsis algorithms, performance alone doesn’t predict victory
As new AI models for predicting sepsis hit the market, experts say performance alone will not drive adoption by hospitals.
PCOS’s new name is PMOS, a small letter change that required a big scientific process
A revised name for PCOS — polyendocrine metabolic ovarian syndrome, or PMOS — was introduced in a paper published Tuesday.
Opinion: STAT+: Pharma and biotech leaders are destroying their own industry
American biotech leaders are destroying their own industry.
STAT+: Patients jockey for exemptions from Medicaid’s new work requirements
Advocates for people with HIV and sickle cell disease are among those pushing for exemptions from Medicaid’s new work requirements.
Integrating dual-process decision making and social dynamics: A formal modeling framework for addiction.
Currently, formal models of addiction focus either on the complex individual decision-making processes involved in addiction or on the social dynamics of addiction. They do not integrate these two levels, which has been identified as a key shortcoming of current…
Explore the Impacts of Theta Burst Stimulation Over the Right Inferior Frontal Gyrus in Autism Spectrum Disorder: Combination of Clinical Symptoms, Neuropsychological Function and MRI
Conditions: Autism Spectrum Disorder; Theta Burst Stimulation; Right Inferior Frontal Gyrus Interventions: Device: intermittent theta burst stimulation Sponsors: Chang Gung Memorial Hospital Recruiting
Psilocybin-Assisted Therapy as a Treatment for Depression
Conditions: Depression Interventions: Drug: Psilocybin (Usona Institute) Sponsors: Washington University School of Medicine Not yet recruiting
Understanding and Targeting Self-Regulatory Control in Bulimia Nervosa
Conditions: Bulimia Nervosa; Feeding and Eating Disorders; Mental Disorders Interventions: Other: Real fNIRS Neurofeedback; Other: Sham-Control fNIRS Neurofeedback; Other: SmartPhone Intervention Sponsors: Icahn School of Medicine at Mount Sinai Not yet recruiting
Incorporating Narrative Into the Treatment of Youth With Anorexia Nervosa (Virtual)
Conditions: Anorexia Nervosa Interventions: Behavioral: Narrative Medicine (NM) Workshop Series Sponsors: University of California, San Francisco Recruiting
Researchers develop innovative model for risk assessment for hypertrophic cardiomyopathy
NIH-funded study incorporates new measures to better predict outcomes in chronic heart condition.
Case Report: Recurrent pathogenic mutation c.110G>A in DHDDS gene
Recent studies have demonstrated the close association of mutations in the dehydrodolichyl diphosphate synthase (DHDDS) gene with neurodevelopmental disorders and the onset of epilepsy. This report describes a female patient harboring a de novo heterozygous variant c.110G>A (p.Arg37His) in the…
Application of neuromodulation techniques in irritable bowel syndrome
Irritable bowel syndrome (IBS) is a gut-brain interaction disorder characterized by abdominal pain/abdominal discomfort accompanied by changes in bowel motility. Its pathogenesis involves the interaction of multiple factors, including abnormalities of the brain-gut axis, intestinal microbiota dysbiosis, and visceral hypersensitivity.…
Long-term neurodevelopment in preterm neonates with necrotizing enterocolitis: systematic review and meta-analysis
IntroductionNecrotizing enterocolitis (NEC) is a common complication in preterm infants and is associated with significant mortality and long-term morbidity, including gastrointestinal sequelae, brain injury, and developmental delays. This systematic review and meta-analysis examines long-term neurodevelopmental outcomes in infants born at…