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Exercise as a multiscale recalibration of stress-related homeostatic balance
Chronic stress disrupts homeostasis in the brain and body, leading to anxiety, depression, and cardiovascular and metabolic dysfunction. Although exercise can counter these effects, the mechanisms are scattered across fields and not yet integrated. This review proposes a multi-scale framework.…
Task-aligned outcome learning in psychiatry: reducing endpoint dilution
Psychiatric research relies on well-defined outcomes for standardization, comparability, and replication, yet investigators often fix broad endpoints before knowing which symptom domains carry task-relevant signal. Even when psychometrically sound and clinically useful, composite measures can dilute predictive information and attenuate…
The correlation between phubbing and depression anxiety stress of first-year medical students: the mediating role of sedentary behavior
BackgroundFreshmen often experience challenges when adjusting from high school to college, which may elevate levels of depression, anxiety, and stress. This phenomenon is particularly pronounced in medical schools, where the overall academic atmosphere is widely regarded as exceptionally demanding and…
Autonomic nervous system reactions to secondary exposure to disaster-related imagery
AimThis study investigated how disaster-related imagery affects emotional and autonomic nervous system (ANS) responses, using heart rate (HR) and heart rate variability (HRV), in individuals with indirect exposure to the 2011 Great East Japan Earthquake (GEJE).MethodsThirty-six healthy adults who had…
Joint latent profiles of death anxiety and treatment adherence in HCC patients
BackgroundHepatocellular carcinoma (HCC), one of the leading contributors to the global cancer burden, often places patients in a dual predicament of pronounced death anxiety and suboptimal treatment adherence. Prior research has largely treated death anxiety and adherence as independent, homogeneous…
Circling back to RNA vaccines
Nature Biotechnology, Published online: 11 May 2026; doi:10.1038/s41587-026-03155-8While circRNA is often framed as a more stable, longer-lasting alternative to linear mRNA, its real-world advantages remain largely theoretical, and it is unclear whether greater molecular stability will translate into meaningful clinical…
A new treatment for preterm pre-eclampsia could benefit mother and child
Nature Medicine, Published online: 11 May 2026; doi:10.1038/s41591-026-04400-yA first-in-human trial involving selective removal of the placental protein sFlt-1 in preterm pre-eclampsia provides critical safety data, and could mark the beginning of a new era of targeted therapy for this potentially…
The connection between periods and mental health
Plans to oust Makary, a looming Supreme Court deadline on mifepristone, and other health news from Morning Rounds
Animal skin disease confirmed in clusters of European men who have sex with men
European researchers have diagnosed a number of men who have sex with other men with a skin disease that normally infects livestock.
STAT+: Provider, insurer groups rush to shape No Surprises Act arbitration rules
Doctors and insurers are battling to reshape the controversial No Surprises Act arbitration process, which has long frustrated both sides.
Opinion: AI doctors should be licensed. Here’s a framework to do that
A state-by-state approach to clinical AI won’t work. Here’s a framework that can.
STAT+: Medicare is spending far less than expected on new Alzheimer’s drugs
Adoption has been slow with new Alzheimer’s drugs because the treatments are complicated to administer and the benefits are uncertain.
Bed Rest With a Short Cervix on Preterm Birth
Conditions: Preterm Birth; Cervical Insufficiency; Bed Rest; Pregnancy Complications; Immobilization; Depression, Postpartum; Pregnancy Outcome; Infant, Premature; Uterine Cervical Incompetence; Premature Birth; Obstetric Labor, Premature; Physical Activity; Bone Density Interventions: Behavioral: Activity Restriction; Behavioral: No Activity Restriction Sponsors: Julie Glavind; Aarhus…
Health And Response: Digital Markers for Outcomes in Perinatal Depression Treatment Study
Conditions: Depression; Perinatal Depression Interventions: Behavioral: Perinatal depression online cognitive-behavioral therapy course; Behavioral: Clinical care (psychotherapy sessions) Sponsors: University of California, Los Angeles; Foundation for Women's Health Not yet recruiting
AcceXible Speech-Based Screening for Depression and Anxiety in University Students (UAQ, Mexico)
Conditions: Depression - Major Depressive Disorder; Anxiety Interventions: Device: Accexible Sponsors: Accexible; Universidad Autónoma de Querétaro Not yet recruiting
Calming Minds Study
Conditions: Anxiety; Anxiety Depression; Worry; Depression; Rumination - Thoughts Interventions: Behavioral: Be Specific; Behavioral: Be Kind; Behavioral: Be Present; Behavioral: Break Habit; Behavioral: Psychoeducation Sponsors: University of California, Los Angeles; University of Exeter Not yet recruiting
Low-dose digoxin in patients with heart failure with reduced or mildly reduced ejection fraction: a randomized controlled trial
Nature Medicine, Published online: 10 May 2026; doi:10.1038/s41591-026-04406-6As presented at the 2026 ESC Heart Failure Congress, in a large randomized controlled trial in patients with heart failure with reduced or mildly reduced ejection fraction, treatment with low-dose digoxin was generally…
The microRNA inhibitor CDR132L in patients with reduced left ventricular ejection fraction after myocardial infarction: a randomized phase 2 trial
Nature Medicine, Published online: 10 May 2026; doi:10.1038/s41591-026-04408-4As presented at the 2026 ESC Heart Failure Congress, in a phase 2 randomized trial in patients with heart failure with reduced left ventricular ejection fraction after myocardial infarction, treatment with CDR132L, an…
Experts wonder ‘Where is the CDC?’ as hantavirus outbreak unfolds
The CDC is playing an unusually small, and quiet, role in responding to the hantavirus outbreak.