News Feed
Secondary School Staff Engagement With a School-Based Physical Activity and Sedentary Behavior Initiative Website: Implementation Trial During National Scale-Up
Background: Online platforms are increasingly used to deliver training and implementation resources for large-scale, school-based physical activity initiatives, and understanding behavioral engagement with these platforms is important because it provides an early indicator of…
News
3069 results
What Anthropic’s latest AI discovery does—and doesn’t—show
This story originally appeared in The Algorithm, our weekly newsletter on AI. To get stories like this in your inbox first, sign up here. Anthropic—currently the world’s most valuable AI company, with a nearly $1 trillion valuation—has a reputation for publishing…
STAT+: Dementia study replicates promising outcomes following risk-reduction strategies
A dementia prevention trial praised as a "landmark" effort further demonstrated the promise of structured programs tailored to local cultures.
AI Agents Are Coming: 5-Stage Taxonomy of Language-Based AI Systems for Psychiatry, Psychotherapy, and Counseling
The rapid evolution of large language models has accelerated the development of agentic artificial intelligence (AI) systems capable of pursuing autonomous goals, creating an urgent need for structural frameworks in psychiatry and psychotherapy. While existing classifications often draw parallels to…
STAT+: UnitedHealth’s questionable review, and more MA stars lawsuits
UnitedHealth touts a new home care audit, and more health insurers sue CMS over Medicare Advantage quality ratings.
Martha Lillard, last U.S. polio patient using iron lung, dies at 78 in Oklahoma
Martha Lillard, last U.S. polio patient using iron lung, has died at 78 in Oklahoma.
STAT+: All eyes on data on Biogen’s tau therapy
The year of daraxonrasib, a wearable for a myeloma drug, and more biotech news from The Readout
The Download: a donor conception cap and world models for AI
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Sperm donors need limits, says a European fertility group Ties van der Meer doesn’t know how…
Evaluating the detection of small brain lesions in magnetic resonance using deep learning
IntroductionDetecting brain lesions using Artificial Intelligence methods has been a focus of prior research, with numerous datasets supporting this task to improve clinical results. However, evaluation metrics and reported results often summarise overall performance without considering variations in lesion size.…
Diagnostic redirection in dementia-first spinocerebellar ataxia type 17: a family-based case report and focused literature review
BackgroundSpinocerebellar ataxia type 17 (SCA17) is an autosomal dominant repeat-expansion disorder with marked phenotypic heterogeneity. Cognitive and neuropsychiatric symptoms may dominate early recognition and initially suggest a primary dementia syndrome. We aimed to illustrate diagnostic redirection in dementia-first SCA17 through…
Cereblon-related mild intellectual disability disrupts response inhibition and uniformity of group–individual strategies
Temporal processing, including duration discrimination, is essential for survival and communication across species. Intellectual disability (ID), which can arise from diverse causes, including mutation in Cereblon (CRBN) gene, impairs duration discrimination. CRBN-related ID is associated with abnormal cognitive behaviors and…
Gerstmann-Sträussler-Scheinker syndrome with unexpected concomitant GRN variant: case report
The objective is to report a patient with Gerstmann-Sträussler-Scheinker syndrome caused by a pathogenic PRNP P102L variant harboring an unexpected concomitant pathogenic GRN variant p.R110X and to discuss the potential contribution of combined genetic pathology to the clinical and neuroimaging…
Nucleus accumbens DRD2 receptor agonism attenuates escape behavior
Animals learn to approach and escape stimuli in their environment, in part through the representation of rewarding or aversive outcomes in the nucleus accumbens (NAc). The regulation of reward motivation in the NAc by dopamine signaling at DRD1 and DRD2…
Attention-deficit/hyperactivity disorder and chronic pain: a scoping review of epidemiology, clinical phenotypes, mechanisms, and treatment
IntroductionEmerging evidence suggests a potential association between attention-deficit/hyperactivity disorder (ADHD) and chronic pain; however, extant findings are dispersed across disciplines and have not yet been comprehensively synthesized. This scoping review aimed to systematically map the epidemiological evidence, clinical phenotypes, proposed…
Prevalence and predictors of HCV infection among hospitalized psychiatric patients in Poland
BackgroundPatients with mental disorders are at increased risk of hepatitis C virus (HCV) infection, yet the prevalence of HCV among patients in Polish psychiatric ward remains unknown.MethodsA cross-sectional survey was conducted in Poland from 2021 to 2023 in psychiatric wards.…
Family caregivers’ involvement in home-based recovery for patients with schizophrenia: a qualitative study in Beijing, China
BackgroundFamily caregivers play critical roles in supporting the home-based recovery of patients with schizophrenia, but they often encounter substantial challenges and receive insufficient systemic support. Understanding caregivers’ involvement in home-based recovery is essential for aligning community mental health services with…
Case Report: A novel de novo heterozygous truncating mutation in MED12L identified in a Chinese autistic boy
BackgroundAutism spectrum disorder (ASD) is a highly heterogeneous neurodevelopmental disorder. A previous study by Nizon et al. indicated that some children with intellectual disability (ID) carrying de novo MED12L mutations exhibited mild to moderate autistic features. However, the relationship between MED12L…
Intracranial hypertension after MECT: successful transition to rTMS for refractory auditory hallucinations: a case report
A 21-year-old female patient with schizophrenia, whose primary symptom was refractory auditory hallucinations, developed intracranial hypertension syndrome following her first session of modified electroconvulsive therapy (MECT), presenting with severe headache, projectile vomiting, diplopia and meningeal signs. She subsequently received 1 Hz…
High-resolution reconstruction of cell-type-specific transcriptional regulatory processes from bulk sequencing samples
Nature Biotechnology, Published online: 13 July 2026; doi:10.1038/s41587-026-03218-wDeepDETAILS enables cross-modality deconvolution of bulk sequencing samples.
An anti-PMEL antibody−drug conjugate with a Gq/11 inhibitor payload in GNAQ/GNA11-mutant melanomas: a phase 1 trial
Nature Medicine, Published online: 13 July 2026; doi:10.1038/s41591-026-04518-zIn a phase 1 trial, treatment with the antibody−drug conjugate DYP688, targeting PMEL and delivering a Gq/11 inhibitor, in patients with GNAQ/GNA11-mutant metastatic uveal melanoma or other GNAQ/GNA11-mutant melanomas, showed acceptable safety and…
Caregivers brace for pay cuts, and maybe homelessness
A game-changer in pancreatic cancer, a vaccine skeptical HHS nom, and more health news from Morning Rounds
News Feed
Secondary School Staff Engagement With a School-Based Physical Activity and Sedentary Behavior Initiative Website: Implementation Trial During National Scale-Up
Background: Online platforms are increasingly used to deliver training and implementation resources for large-scale, school-based physical activity initiatives, and understanding behavioral engagement with these platforms is important because it provides an early indicator of…
News
3069 results
What Anthropic’s latest AI discovery does—and doesn’t—show
This story originally appeared in The Algorithm, our weekly newsletter on AI. To get stories like this in your inbox first, sign up here. Anthropic—currently the world’s most valuable AI company, with a nearly $1 trillion valuation—has a reputation for publishing…
STAT+: Dementia study replicates promising outcomes following risk-reduction strategies
A dementia prevention trial praised as a "landmark" effort further demonstrated the promise of structured programs tailored to local cultures.
AI Agents Are Coming: 5-Stage Taxonomy of Language-Based AI Systems for Psychiatry, Psychotherapy, and Counseling
The rapid evolution of large language models has accelerated the development of agentic artificial intelligence (AI) systems capable of pursuing autonomous goals, creating an urgent need for structural frameworks in psychiatry and psychotherapy. While existing classifications often draw parallels to…
STAT+: UnitedHealth’s questionable review, and more MA stars lawsuits
UnitedHealth touts a new home care audit, and more health insurers sue CMS over Medicare Advantage quality ratings.
Martha Lillard, last U.S. polio patient using iron lung, dies at 78 in Oklahoma
Martha Lillard, last U.S. polio patient using iron lung, has died at 78 in Oklahoma.
STAT+: All eyes on data on Biogen’s tau therapy
The year of daraxonrasib, a wearable for a myeloma drug, and more biotech news from The Readout
The Download: a donor conception cap and world models for AI
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Sperm donors need limits, says a European fertility group Ties van der Meer doesn’t know how…
Evaluating the detection of small brain lesions in magnetic resonance using deep learning
IntroductionDetecting brain lesions using Artificial Intelligence methods has been a focus of prior research, with numerous datasets supporting this task to improve clinical results. However, evaluation metrics and reported results often summarise overall performance without considering variations in lesion size.…
Diagnostic redirection in dementia-first spinocerebellar ataxia type 17: a family-based case report and focused literature review
BackgroundSpinocerebellar ataxia type 17 (SCA17) is an autosomal dominant repeat-expansion disorder with marked phenotypic heterogeneity. Cognitive and neuropsychiatric symptoms may dominate early recognition and initially suggest a primary dementia syndrome. We aimed to illustrate diagnostic redirection in dementia-first SCA17 through…
Cereblon-related mild intellectual disability disrupts response inhibition and uniformity of group–individual strategies
Temporal processing, including duration discrimination, is essential for survival and communication across species. Intellectual disability (ID), which can arise from diverse causes, including mutation in Cereblon (CRBN) gene, impairs duration discrimination. CRBN-related ID is associated with abnormal cognitive behaviors and…
Gerstmann-Sträussler-Scheinker syndrome with unexpected concomitant GRN variant: case report
The objective is to report a patient with Gerstmann-Sträussler-Scheinker syndrome caused by a pathogenic PRNP P102L variant harboring an unexpected concomitant pathogenic GRN variant p.R110X and to discuss the potential contribution of combined genetic pathology to the clinical and neuroimaging…
Nucleus accumbens DRD2 receptor agonism attenuates escape behavior
Animals learn to approach and escape stimuli in their environment, in part through the representation of rewarding or aversive outcomes in the nucleus accumbens (NAc). The regulation of reward motivation in the NAc by dopamine signaling at DRD1 and DRD2…
Attention-deficit/hyperactivity disorder and chronic pain: a scoping review of epidemiology, clinical phenotypes, mechanisms, and treatment
IntroductionEmerging evidence suggests a potential association between attention-deficit/hyperactivity disorder (ADHD) and chronic pain; however, extant findings are dispersed across disciplines and have not yet been comprehensively synthesized. This scoping review aimed to systematically map the epidemiological evidence, clinical phenotypes, proposed…
Prevalence and predictors of HCV infection among hospitalized psychiatric patients in Poland
BackgroundPatients with mental disorders are at increased risk of hepatitis C virus (HCV) infection, yet the prevalence of HCV among patients in Polish psychiatric ward remains unknown.MethodsA cross-sectional survey was conducted in Poland from 2021 to 2023 in psychiatric wards.…
Family caregivers’ involvement in home-based recovery for patients with schizophrenia: a qualitative study in Beijing, China
BackgroundFamily caregivers play critical roles in supporting the home-based recovery of patients with schizophrenia, but they often encounter substantial challenges and receive insufficient systemic support. Understanding caregivers’ involvement in home-based recovery is essential for aligning community mental health services with…
Case Report: A novel de novo heterozygous truncating mutation in MED12L identified in a Chinese autistic boy
BackgroundAutism spectrum disorder (ASD) is a highly heterogeneous neurodevelopmental disorder. A previous study by Nizon et al. indicated that some children with intellectual disability (ID) carrying de novo MED12L mutations exhibited mild to moderate autistic features. However, the relationship between MED12L…
Intracranial hypertension after MECT: successful transition to rTMS for refractory auditory hallucinations: a case report
A 21-year-old female patient with schizophrenia, whose primary symptom was refractory auditory hallucinations, developed intracranial hypertension syndrome following her first session of modified electroconvulsive therapy (MECT), presenting with severe headache, projectile vomiting, diplopia and meningeal signs. She subsequently received 1 Hz…
High-resolution reconstruction of cell-type-specific transcriptional regulatory processes from bulk sequencing samples
Nature Biotechnology, Published online: 13 July 2026; doi:10.1038/s41587-026-03218-wDeepDETAILS enables cross-modality deconvolution of bulk sequencing samples.
An anti-PMEL antibody−drug conjugate with a Gq/11 inhibitor payload in GNAQ/GNA11-mutant melanomas: a phase 1 trial
Nature Medicine, Published online: 13 July 2026; doi:10.1038/s41591-026-04518-zIn a phase 1 trial, treatment with the antibody−drug conjugate DYP688, targeting PMEL and delivering a Gq/11 inhibitor, in patients with GNAQ/GNA11-mutant metastatic uveal melanoma or other GNAQ/GNA11-mutant melanomas, showed acceptable safety and…
Caregivers brace for pay cuts, and maybe homelessness
A game-changer in pancreatic cancer, a vaccine skeptical HHS nom, and more health news from Morning Rounds