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Sleep and circadian rhythm disruptions in animal models of temporal lobe epilepsy
Temporal lobe epilepsy (TLE) is frequently accompanied by disruptions to sleep and circadian rhythms, which substantially contribute to disease burden. Human studies are often confounded by antiseizure medications, limiting insight into underlying mechanisms. Animal models therefore provide critical opportunities to…
Development and validation of machine learning models for predicting functional outcome after low-dose alteplase in the extended time window for acute ischemic stroke
BackgroundThis study aims to develop machine learning (ML) models to predict 90-day functional outcomes for acute ischemic stroke (AIS) patients receiving thrombolysis with low-dose alteplase at 0.6 mg/kg between 4.5 and 9 h after symptom onset.MethodsWe conducted a retrospective analysis…
A multichannel MEG time–frequency analysis framework for detecting stage -specific effects of spatial distraction in visual-spatial working memory
IntroductionSpatial distraction can disrupt visual-spatial working memory (VSWM), but its stage-dependent effects on multichannel neural dynamics remain insufficiently characterized. This study presents a multichannel magnetoencephalography (MEG) time—frequency analysis framework to detect stage-specific oscillatory responses to spatial distraction during a VSWM…
Two-year longitudinal neuropsychological monitoring after unilateral and staged bilateral subthalamic nucleus deep brain stimulation
IntroductionDeep brain stimulation (DBS) is an increasingly popular therapeutic method for treating motor symptoms in Parkinson’s disease, but its impact on non-motor symptoms in long-term follow-up remains debated.MethodThe primary objective of this study was to monitor the cognitive functioning, mood,…
Can exercise combined with transcranial direct current stimulation improve cognitive function in older adults? A systematic review and meta-analysis
ObjectiveThis study investigated whether combining exercise with transcranial direct current stimulation (tDCS) improves overall cognition, memory, and executive function in older adults.MethodsFollowing PRISMA guidelines, we systematically searched databases including PubMed, Web of Science, CNKI, and Wan Fang for randomized controlled…
ADOPT model combined with structured health education alleviates the preoperative anxiety of patients undergoing preventive ileostomy
ObjectiveThis study aimed to evaluate the efficacy of the ADOPT (Attitude-Definition-Openmind-Plan-Try it out) model combined with structured health education in alleviating preoperative anxiety in patients undergoing preventive ileostomy for rectal cancer.MethodsThis is a randomized controlled trial. A total of 60…
Computer-based tree drawing test in adolescents and adults with depression
ObjectiveTo evaluate the value of the computer-based Tree Drawing Test in the auxiliary diagnosis of depressive disorders and to analyze the differences in the performance of adolescent and adult depression patients in the Tree Drawing Projection Test.MethodsThis study was conducted…
Adaptation of behavioural activation for adolescents with mild to moderate intellectual disabilities and depression
IntroductionAdolescents with intellectual disabilities are at increased risk for mental health problems and depression. Despite this, there is currently no evidence for effective psychological interventions for treating low mood and depression in this population. Behavioural activation has been identified as…
Development and validation of a comprehensive prevention-focused intervention package for problematic digital technology use among youth: a multi-site study protocol
BackgroundProblematic use of digital technology among children, adolescents, and young adults is associated with adverse health, behavioural, interpersonal, social, academic and vocational outcomes. Most existing research focuses on treatment oriented interventions. Prevention focused interventions are limited. This is especially true…
Virtual reality-based inhibition training influences food-related responses: no additional effects of repetitive transcranial magnetic stimulation
Combining cognitive inhibition training with brain stimulation techniques has received increasing attention as a potential approach to modulating maladaptive food craving and food intake. Building on previous work in this line of research, the current study examined whether virtual reality…
The aging scientific workforce collides with rising fabricating citations in medical journals
The latest in the hantavirus cruise ship saga, why these former officials left the FDA, and more health news from Morning Rounds
Here’s how technology transformed babymaking
Technology is changing the way we make babies. The pioneering work of the scientists who invented IVF led to the birth of the first “test tube baby” in 1978. We’ve come a long, long way since then. This week, I’ve…
Opinion: We need more men in nursing
Men make up just 12% of nurses nationally. That needs to change.
Opinion: STAT+: Medicare’s new RAPID pathway is a breakthrough for adults. Children are still waiting
“The pediatric and orphan pipeline is already the smallest, slowest, and least capitalized segment of the device industry,” writes Kolaleh Eskandanian.
Why we left the FDA: Six former officials share their stories
In this week's STATus Report, hear from six former FDA officials on why they left the agency.
AI-Guided CBT for Depression and Anxiety
Conditions: Depression - Major Depressive Disorder; Anxiety Disorders Interventions: Behavioral: AI-Guided Cognitive Behavioral Therapy; Behavioral: Cognitive Behavioral Therapy (CBT) Sponsors: Aleksandra Stojanovic Recruiting
Extended Group Written Exposure Therapy for Comorbid PTSD and BPD (Traits)
Conditions: Posttraumatic Stress Disorder (PTSD); Borderline Personality Disorder (BPD) Interventions: Behavioral: Group Written Exposure Therapy Sponsors: St. Joseph's Healthcare Hamilton Not yet recruiting
Reestablishing Normal Gut-brain Interaction in Anorexia Nervose With Normal Gut Microbiota
Conditions: Anorexia Nervosa Interventions: Biological: Psychotherapy as usual combined with single dose normal gut microbiota; Other: Psychotherapy treatment as usual (TAU) Sponsors: Haukeland University Hospital; The Dam Foundation Not yet recruiting
Ferrimagnetism of ultracold fermions in a multiband Hubbard system
Science, Volume 392, Issue 6798, Page 612-616, May 2026.
Realization of a spin glass in a two-dimensional van der Waals material
Science, Volume 392, Issue 6798, Page 624-628, May 2026.