News Feed
Discharge Mobility After Osteoporotic Thoracolumbar Fractures Using a 2-Stage Machine Learning Prediction Model: Prospective Cohort Study
Background: Discharge mobility after osteoporotic vertebral fractures is heterogeneous and difficult to predict at admission. Machine learning offers structured approaches for multiclass functional outcome prediction, but existing models predominantly address binary end points and…
Single-Nucleus Multi-Omic Profiling Reveals Muscle Genetic Regulation Layer
Population-scale transcriptomics and chromatin accessibility profiling uncover thousands of disease-associated regulatory signals missed by transcriptomic analyses, raising questions about how many therapeutic targets are unknown. The post Single-Nucleus Multi-Omic Profiling Reveals Muscle Genetic Regulation…
Short-Term Low-Fat Diet Has Lasting Inflammatory Disease Benefits
Switching low-fat diet for just a few days at the onset of an inflammatory disease such as psoriasis could impact its trajectory in both the short and long term, according to a preclinical study.…
News
3069 results
A novel mutation in SETD1A is associated with early-onset epilepsy—a rare case report
SET Domain Containing 1A (SETD1A) is a histone H3K4 methyltransferase implicated in neurodevelopmental disorders. Pathogenic variants in this gene are associated with schizophrenia, intellectual disability, and epilepsy. Here, whole-exome sequencing and Sanger sequencing were performed on a 4-year-old Chinese girl…
Altered brain entropy and functional connectivity patterns in peritoneal dialysis patients
ObjectiveTo explore abnormal changes in brain entropy (BEN) and resting-state functional connectivity (RSFC) in peritoneal dialysis (PD) patients and their associations with cognitive impairment (CI).MethodsFifty-three PD patients and 49 age-, gender-, and education-matched healthy controls (HCs) were enrolled. Resting-state functional…
An end-to-end pipeline for automated fetal brain segmentation and biometry from 3D SSFP MRI
Fetal magnetic resonance imaging (MRI) plays an essential role for the evaluation of fetal abnormalities, offering improved visualization of developing brain structures and superior soft tissue contrast in comparison to other imaging modalities. Accurate and reproducible assessment of fetal brain…
Local field potentials for target localization in centromedian deep brain stimulation for epilepsy
ObjectiveTo evaluate whether local field potential (LFP) spectral profiles can serve as a candidate “spectral fingerprint” for physiological confirmation of centromedian-parafascicular (CM–Pf) targeting during thalamic deep brain stimulation (DBS) for drug resistant epilepsy (DRE).MethodsThis is a retrospective study of 10…
Freezing of gait and the effects of vibrotactile cueing in Parkinson’s disease–a study protocol of a cross-sectional multimodal brain imaging approach in virtual walking scenarios
BackgroundFreezing of gait (FOG) is one of the most debilitating motor symptoms in Parkinson’s disease (PD), affecting a substantial proportion of people with PD. Numerous hypothetical mechanisms exist, attempting to explain FOG. Current evidence originated from stationary measures in lying…
Autistic- and attention-deficit/hyperactivity disorder-like traits: differential associations with burnout, depression and anxiety, and empathy among Japanese junior residents
IntroductionBurnout, depression, and anxiety are major concerns among physicians because they affect individual well-being, patient care, and healthcare systems. Neurodevelopmental traits, including autistic-like traits (ALTs) and attention-deficit/hyperactivity disorder (ADHD)-like traits (ADHLTs), may increase vulnerability to psychological distress. However, little is…
Treating addiction with an addictive drug: the ketamine paradox revisited
BackgroundSubstance use disorders (SUDs) and treatment-resistant depression (TRD) remain a major global health challenge, marked by high relapse rates and limited long-term effectiveness of existing treatments. Ketamine, a glutamatergic modulator with rapid neuroplastic effects, has emerged as a novel intervention…
Loneliness, rumination, and adolescent psychological crisis in China: a pilot moderated mediation study
BackgroundAdolescent psychological crisis—encompassing depressive disorder, anxiety disorder, and suicidal ideation—is a major public health challenge. One in five adolescents experiences a clinically significant mental health condition globally. Loneliness is a well-documented, modifiable risk factor for these outcomes. However, the exact…
Real-world outcomes of intranasal esketamine and intravenous ketamine induction therapy for treatment-resistant depression in a community clinic: a retrospective cohort study
IntroductionIntravenous (IV) ketamine and intranasal esketamine are NMDA receptor antagonists used for treatment-resistant depression (TRD). Both have demonstrated efficacy in controlled trials, but observational evidence from real-world community settings is limited.MethodsWe conducted a single-center retrospective cohort study of adults aged…
Autism service barriers for Latine children and their families: a participatory approach to adapting autism diagnostic care
IntroductionLatine children from families with limited English proficiency (LEP) experience barriers to timely autism diagnosis resulting in persistent health inequities. This participatory mixed-methods study examined these barriers and identified multi-level strategies to adapt diagnostic care models for Spanish-speaking Latine families.MethodsParticipants…
Biotech’s digital twin dilemma
Nature Biotechnology, Published online: 09 July 2026; doi:10.1038/s41587-026-03211-3From virtual patients to simulated cells and organs-on-chips, digital twins are forecasting disease and guiding drug development. Scientists now must figure out how to define, validate and deploy these models.
High-quality phage assembly from metagenomes with PALACE
Nature Biotechnology, Published online: 09 July 2026; doi:10.1038/s41587-026-03188-zPALACE combines homology features and deep learning to improve phage assembly from metagenomics.
A second chance for gene therapy to restore natural hearing
Nature Medicine, Published online: 09 July 2026; doi:10.1038/s41591-026-04512-5The immune-privileged environment of the inner ear permits sequential bilateral gene therapy for one form of congenital deafness, which adds to growing evidence of the feasibility, safety and efficacy of this innovative curative…
Challenges and future directions for multiple sclerosis after the 2024 McDonald diagnostic criteria
Nature Medicine, Published online: 09 July 2026; doi:10.1038/s41591-026-04490-8The 2024 revision of the McDonald diagnostic criteria is an important step toward earlier and more inclusive diagnosis of multiple sclerosis. Realizing its full potential will require continued refinement of biomarkers, disease stratification…
When the real world becomes the trial
Nature Medicine, Published online: 09 July 2026; doi:10.1038/s41591-026-04484-6Once confined to post-market surveillance, real-world evidence is now being used to emulate trials, guide approvals and even run studies in real time, forcing a rethink of what constitutes a clinical trial.
KRAS-G12D inhibitor HRS-4642 plus chemotherapy in advanced KRASG12D-mutant pancreatic cancer: a phase 1b/2 trial
Nature Medicine, Published online: 09 July 2026; doi:10.1038/s41591-026-04538-9In phase 1b/2 trial, the treatment of patients with metastatic KRASG12D-mutant pancreatic cancer, the intravenously delivered KRAS-G12D inhibitor HRS-4642 plus nab-paclitaxel and gemcitabine led to encouraging clinical response rates that support investigation in…
Biological aging clocks in health and disease
Nature Medicine, Published online: 09 July 2026; doi:10.1038/s41591-026-04495-3This review outlines the state of the art of biological clocks and how they could help understand pathobiology, reduce the burden of disease and extend healthspan.
Who’s going to run the FDA?
RFK Jr.'s list of Covid vaccine injuries, a father's quest to cure his daughter, and more health news from Morning Rounds
STAT+: 931 days. The drug approval scandal hiding in plain sight
Two years, six months, and 18 days have elapsed since Northwest Biotherapeutics submitted its brain cancer treatment for regulatory approval.
STAT+: AstraZeneca, Ionis report major trial failure with heart disease drug
AstraZeneca and Ionis reported a notable trial failure Thursday in a heart disease that's become an increasingly competitive market for drugmakers.
News Feed
Discharge Mobility After Osteoporotic Thoracolumbar Fractures Using a 2-Stage Machine Learning Prediction Model: Prospective Cohort Study
Background: Discharge mobility after osteoporotic vertebral fractures is heterogeneous and difficult to predict at admission. Machine learning offers structured approaches for multiclass functional outcome prediction, but existing models predominantly address binary end points and…
Single-Nucleus Multi-Omic Profiling Reveals Muscle Genetic Regulation Layer
Population-scale transcriptomics and chromatin accessibility profiling uncover thousands of disease-associated regulatory signals missed by transcriptomic analyses, raising questions about how many therapeutic targets are unknown. The post Single-Nucleus Multi-Omic Profiling Reveals Muscle Genetic Regulation…
Short-Term Low-Fat Diet Has Lasting Inflammatory Disease Benefits
Switching low-fat diet for just a few days at the onset of an inflammatory disease such as psoriasis could impact its trajectory in both the short and long term, according to a preclinical study.…
News
3069 results
A novel mutation in SETD1A is associated with early-onset epilepsy—a rare case report
SET Domain Containing 1A (SETD1A) is a histone H3K4 methyltransferase implicated in neurodevelopmental disorders. Pathogenic variants in this gene are associated with schizophrenia, intellectual disability, and epilepsy. Here, whole-exome sequencing and Sanger sequencing were performed on a 4-year-old Chinese girl…
Altered brain entropy and functional connectivity patterns in peritoneal dialysis patients
ObjectiveTo explore abnormal changes in brain entropy (BEN) and resting-state functional connectivity (RSFC) in peritoneal dialysis (PD) patients and their associations with cognitive impairment (CI).MethodsFifty-three PD patients and 49 age-, gender-, and education-matched healthy controls (HCs) were enrolled. Resting-state functional…
An end-to-end pipeline for automated fetal brain segmentation and biometry from 3D SSFP MRI
Fetal magnetic resonance imaging (MRI) plays an essential role for the evaluation of fetal abnormalities, offering improved visualization of developing brain structures and superior soft tissue contrast in comparison to other imaging modalities. Accurate and reproducible assessment of fetal brain…
Local field potentials for target localization in centromedian deep brain stimulation for epilepsy
ObjectiveTo evaluate whether local field potential (LFP) spectral profiles can serve as a candidate “spectral fingerprint” for physiological confirmation of centromedian-parafascicular (CM–Pf) targeting during thalamic deep brain stimulation (DBS) for drug resistant epilepsy (DRE).MethodsThis is a retrospective study of 10…
Freezing of gait and the effects of vibrotactile cueing in Parkinson’s disease–a study protocol of a cross-sectional multimodal brain imaging approach in virtual walking scenarios
BackgroundFreezing of gait (FOG) is one of the most debilitating motor symptoms in Parkinson’s disease (PD), affecting a substantial proportion of people with PD. Numerous hypothetical mechanisms exist, attempting to explain FOG. Current evidence originated from stationary measures in lying…
Autistic- and attention-deficit/hyperactivity disorder-like traits: differential associations with burnout, depression and anxiety, and empathy among Japanese junior residents
IntroductionBurnout, depression, and anxiety are major concerns among physicians because they affect individual well-being, patient care, and healthcare systems. Neurodevelopmental traits, including autistic-like traits (ALTs) and attention-deficit/hyperactivity disorder (ADHD)-like traits (ADHLTs), may increase vulnerability to psychological distress. However, little is…
Treating addiction with an addictive drug: the ketamine paradox revisited
BackgroundSubstance use disorders (SUDs) and treatment-resistant depression (TRD) remain a major global health challenge, marked by high relapse rates and limited long-term effectiveness of existing treatments. Ketamine, a glutamatergic modulator with rapid neuroplastic effects, has emerged as a novel intervention…
Loneliness, rumination, and adolescent psychological crisis in China: a pilot moderated mediation study
BackgroundAdolescent psychological crisis—encompassing depressive disorder, anxiety disorder, and suicidal ideation—is a major public health challenge. One in five adolescents experiences a clinically significant mental health condition globally. Loneliness is a well-documented, modifiable risk factor for these outcomes. However, the exact…
Real-world outcomes of intranasal esketamine and intravenous ketamine induction therapy for treatment-resistant depression in a community clinic: a retrospective cohort study
IntroductionIntravenous (IV) ketamine and intranasal esketamine are NMDA receptor antagonists used for treatment-resistant depression (TRD). Both have demonstrated efficacy in controlled trials, but observational evidence from real-world community settings is limited.MethodsWe conducted a single-center retrospective cohort study of adults aged…
Autism service barriers for Latine children and their families: a participatory approach to adapting autism diagnostic care
IntroductionLatine children from families with limited English proficiency (LEP) experience barriers to timely autism diagnosis resulting in persistent health inequities. This participatory mixed-methods study examined these barriers and identified multi-level strategies to adapt diagnostic care models for Spanish-speaking Latine families.MethodsParticipants…
Biotech’s digital twin dilemma
Nature Biotechnology, Published online: 09 July 2026; doi:10.1038/s41587-026-03211-3From virtual patients to simulated cells and organs-on-chips, digital twins are forecasting disease and guiding drug development. Scientists now must figure out how to define, validate and deploy these models.
High-quality phage assembly from metagenomes with PALACE
Nature Biotechnology, Published online: 09 July 2026; doi:10.1038/s41587-026-03188-zPALACE combines homology features and deep learning to improve phage assembly from metagenomics.
A second chance for gene therapy to restore natural hearing
Nature Medicine, Published online: 09 July 2026; doi:10.1038/s41591-026-04512-5The immune-privileged environment of the inner ear permits sequential bilateral gene therapy for one form of congenital deafness, which adds to growing evidence of the feasibility, safety and efficacy of this innovative curative…
Challenges and future directions for multiple sclerosis after the 2024 McDonald diagnostic criteria
Nature Medicine, Published online: 09 July 2026; doi:10.1038/s41591-026-04490-8The 2024 revision of the McDonald diagnostic criteria is an important step toward earlier and more inclusive diagnosis of multiple sclerosis. Realizing its full potential will require continued refinement of biomarkers, disease stratification…
When the real world becomes the trial
Nature Medicine, Published online: 09 July 2026; doi:10.1038/s41591-026-04484-6Once confined to post-market surveillance, real-world evidence is now being used to emulate trials, guide approvals and even run studies in real time, forcing a rethink of what constitutes a clinical trial.
KRAS-G12D inhibitor HRS-4642 plus chemotherapy in advanced KRASG12D-mutant pancreatic cancer: a phase 1b/2 trial
Nature Medicine, Published online: 09 July 2026; doi:10.1038/s41591-026-04538-9In phase 1b/2 trial, the treatment of patients with metastatic KRASG12D-mutant pancreatic cancer, the intravenously delivered KRAS-G12D inhibitor HRS-4642 plus nab-paclitaxel and gemcitabine led to encouraging clinical response rates that support investigation in…
Biological aging clocks in health and disease
Nature Medicine, Published online: 09 July 2026; doi:10.1038/s41591-026-04495-3This review outlines the state of the art of biological clocks and how they could help understand pathobiology, reduce the burden of disease and extend healthspan.
Who’s going to run the FDA?
RFK Jr.'s list of Covid vaccine injuries, a father's quest to cure his daughter, and more health news from Morning Rounds
STAT+: 931 days. The drug approval scandal hiding in plain sight
Two years, six months, and 18 days have elapsed since Northwest Biotherapeutics submitted its brain cancer treatment for regulatory approval.
STAT+: AstraZeneca, Ionis report major trial failure with heart disease drug
AstraZeneca and Ionis reported a notable trial failure Thursday in a heart disease that's become an increasingly competitive market for drugmakers.