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Data-driven decisions in a fast-and-loose world
Science, Volume 392, Issue 6798, Page 585-585, May 2026.
Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration
Science, Volume 392, Issue 6798, May 2026.
ChatGPT Health triage advice falls short in key cases
Nature Medicine, Published online: 07 May 2026; doi:10.1038/s41591-026-04427-1ChatGPT Health showed high accuracy for moderately urgent conditions but frequently overtriaged mild cases and undertriaged emergencies. These findings highlight safety risks at clinical extremes, raising concerns about the reliability of AI tools…
Fraudulent citations, blamed on AI hallucinations, are becoming more common in research papers
“Fabricated” citations that do not reference real academic papers are spreading in the literature, polluting the public record of science, a new study found
Digital Therapeutic Content for Substance Use Disorder Treatment: Development and Evaluation Study
Background: Substance use disorders (SUDs) are a major public health concern, contributing to significant individual and societal costs. Despite this, the uptake of evidence-based pharmacologic and behavioral interventions remains limited. The digital delivery of SUD treatment has emerged as a…
Barriers and Facilitators in the Implementation of the Systematic Medical Appraisal, Referral, and Treatment (SMART) Mental Health Digital Intervention in Rural India: Mixed Methods Process Evaluation Study
Background: An estimated 150 million people have mental health care needs in India, but only 15% are able to access care. Depression and anxiety contribute to a large proportion of mental morbidity. The Systematic Medical Appraisal, Referral, and Treatment (SMART)…
Key takeaways from WHO briefing on hantavirus cruise ship outbreak
Here are key takeaways from a WHO briefing on the hantavirus outbreak aboard a cruise ship.
Oral Small-Molecule GLP-1s Linked to Deep Brain Activity and Reduced Cravings in Mice
New findings in mice suggest that oral small-molecule GLP-1 drugs may directly influence deep brain pathways involved in desire, revealing how these therapies reduce cravings and food-seeking behavior. The post Oral Small-Molecule GLP-1s Linked to Deep Brain Activity and Reduced…
Autism Screening Proposed for Children with Epilepsy
Children with epilepsy should be screened for developmental concerns, following a study suggesting they are up to 10 times more likely than others to have autism. The post Autism Screening Proposed for Children with Epilepsy appeared first on Inside Precision…
Seaport’s IPO adventure, obesity pill battles, and Makary’s troubles
This week on "The Readout LOUD" podcast: Seaport Therapeutics’ successful IPO, obesity pill battles, and the FDA commissioner's White House troubles.
Science is becoming less disruptive. Is an aging workforce to blame?
Most researchers conduct their more disruptive work early in their careers, but as they age, they tend to abandon that groundbreaking energy
Official leading CDC’s cruise ship program retires
The hantavirus outbreak on the MV Hondius has focused the public's attention on cruise ship safety.
Case Report: Relief of long-standing severe motion sickness following stellate ganglion block
BackgroundMotion sickness is a common and often debilitating condition arising from sensory conflict within the vestibular–visual–proprioceptive system, with downstream activation of autonomic and emetic pathways. Despite its prevalence in travel, maritime operations, aviation, spaceflight, and virtual environments, effective prophylaxis remains…
Amyloid-β clearance: an astrocytic perspective
Alzheimer’s disease (AD) represents a major global public health challenge in the 21st century, recognized as the neurodegenerative disorder with the highest mortality rate and socioeconomic burden. The core pathological feature of AD is an imbalance in Aβ production and…
PMAT enhances sexual dimorphism of fear behaviors and facilitates female mice’s generalized contextual fear extinction
Enhanced signaling of dopamine and/or serotonin during highly arousing situations can be reduced in part by monoamine transporters, such as plasma membrane monoamine transporter (PMAT, Slc29a4). An absence of selective pharmacological inhibitors means genetically modified mice constitutively deficient in PMAT…
Serum hypocretin, neurofilament heavy chain, and interleukin-1β as combined predictors of sleep disorders following acute ischemic stroke
BackgroundSleep disorders represent a common and impactful complication following acute ischemic stroke (AIS). This study aimed to identify clinical risk factors and evaluate the predictive value of serum hypocretin (Hcrt), neurofilament heavy chain (NfH), and interleukin-1 beta (IL-1β) for post-stroke…
Introducing a translationally relevant mouse model of radiosurgery-induced unilateral hearing loss
BackgroundStereotactic radiosurgery (SRS) is widely used to treat vestibular schwannomas but may cause irreversible hearing loss due to cochlear toxicity. The underlying mechanisms are not fully understood, and no effective otoprotective therapies exist. We aimed to establish a mouse model…
A two-decade bibliometric analysis (2004–2024) of parental factors in the context of internet gaming disorder research
ObjectiveThis is the first targeted bibliometric analysis which explores the development of scientific production on the relationship between parenting and Internet Gaming Disorder (IGD) over twenty years, emphasizing the central role of the family context in the etiology and maintenance…