News Feed
Discharge Mobility After Osteoporotic Thoracolumbar Fractures Using a 2-Stage Machine Learning Prediction Model: Prospective Cohort Study
Background: Discharge mobility after osteoporotic vertebral fractures is heterogeneous and difficult to predict at admission. Machine learning offers structured approaches for multiclass functional outcome prediction, but existing models predominantly address binary end points and…
Single-Nucleus Multi-Omic Profiling Reveals Muscle Genetic Regulation Layer
Population-scale transcriptomics and chromatin accessibility profiling uncover thousands of disease-associated regulatory signals missed by transcriptomic analyses, raising questions about how many therapeutic targets are unknown. The post Single-Nucleus Multi-Omic Profiling Reveals Muscle Genetic Regulation…
Short-Term Low-Fat Diet Has Lasting Inflammatory Disease Benefits
Switching low-fat diet for just a few days at the onset of an inflammatory disease such as psoriasis could impact its trajectory in both the short and long term, according to a preclinical study.…
News
3069 results
Predictors of unfavorable 3-month functional outcome following intravenous thrombolysis with alteplase in anterior circulation acute ischemic stroke: a prospective cohort study
BackgroundIntravenous thrombolysis with alteplase remains the standard reperfusion strategy for acute ischemic stroke (AIS), yet many patients still experience unfavorable outcomes despite timely treatment, underscoring the need for reliable multimodal prognostic markers.ObjectiveTo identify independent clinical, laboratory, and neuroimaging predictors of…
Neonatal propofol exposure impairs synaptic plasticity and cognition, associated with BAG3 upregulation and disrupted synaptic protein homeostasis
BackgroundPropofol is widely used in pediatric anesthesia, but it has been implicated in adverse effects on brain development following repeated early-life exposure. Bag3, a co-chaperone protein involved in proteostasis and the neuronal stress response, may play a critical role in…
Integrated multi-omics and deep learning analysis reveals neurotransmitter metabolism regulatory mechanisms of Tianwang Buxin Dan
BackgroundTianwang Buxin Dan is a classical Traditional Chinese Medicine formula with documented clinical use in treating neuropsychiatric disorders, yet its molecular mechanisms remain incompletely understood.MethodsWe developed an integrated analytical framework combining transcriptomic and metabolomic profiling with deep learning to investigate…
Cerebrospinal fluid mechanics across CNS barriers: from production, circulation, and clearance to mechanomedicine
BackgroundCerebrospinal fluid (CSF) is often framed as a transport medium, yet its motion and pressure dynamics impose continuous mechanical loading on central nervous system (CNS) barrier and interface systems. These cues span scales—from cilia-scale near-wall shear to craniospinal compliance-driven pulsatility—and…
Automated diagnosis of Sturge–Weber syndrome by detecting leptomeningeal angiomatosis from MRI using a multi-task deep learning framework
ObjectivesSturge–Weber Syndrome (SWS) is a rare neurocutaneous disorder requiring early and accurate diagnosis. This study aims to develop a deep learning framework for automatic diagnosis of SWS by detecting leptomeningeal angiomatosis (LA) in brain magnetic resonance images (MRI).MethodsThis retrospective study…
Knowledge, attitudes, and perception toward new psychoactive substances among Saudi university students: a cross-sectional study
BackgroundNew psychoactive substances (NPS) are defined as chemical compounds that are synthesized or extracted from natural sources with the aim of producing psychoactive effects similar to those produced by controlled substances but not regulated under current legislation. Worldwide, the rise…
Increasing familial engagement in family violence services: a systematically conducted realist review of barriers and facilitators
PurposePhysical, emotional, and sexual violence and abuse occurring between close or extended family members are forms of family violence (FV). The negative impacts of FV are diverse, numerous, and pervasive for all individuals involved. To effectively support individuals experiencing FV,…
Power without limits: exploring emotional regulation, moral authority, and psychiatric overreach through the Wizarding World of Harry Potter
BackgroundPsychiatry has never had more tools to relieve psychological suffering. Psychopharmacology, neuromodulation, early intervention, digital monitoring, and preventive approaches have expanded what clinicians can do. Yet this growing technical capacity also raises an uneasy question: when does care become control?…
Memory-focused therapy: an integrated intervention to reduce trauma symptoms, maladaptive cognitive processes, and emotional distress in Afghan youth
BackgroundAfghan youth continue to face chronic war-related trauma, terrorist violence, and severe disruptions to education and social support systems, resulting in high rates of posttraumatic stress disorder (PTSD), depression, anxiety, and hopelessness. There is a critical need for culturally responsive,…
Parental broad autism phenotype traits and executive function in families of children with autism spectrum disorder
BackgroundParents of children with autism spectrum disorder (ASD) frequently exhibit subclinical Broad Autism Phenotype (BAP) traits, though their relationship with executive function (EF) remains underexplored. This study investigated associations between parental BAP traits and their EF performance.MethodsThe Broad Autism Phenotype…
An AAV vector for glial cells
Nature Biotechnology, Published online: 08 July 2026; doi:10.1038/s41587-026-03193-2Delivery of an in vivo–selected AAV into the glymphatics achieves broad transduction of human glial cells in chimeric mice.
Efficient targeting of human glial progenitor cells in vivo with engineered AAV vectors and glymphatic delivery
Nature Biotechnology, Published online: 08 July 2026; doi:10.1038/s41587-026-03185-2Viral vectors delivered through the brain glymphatics achieve widespread targeting of glial cells.
Oncology must confront hidden side effects
Nature Medicine, Published online: 08 July 2026; doi:10.1038/s41591-026-04554-9As a new generation of cancer drugs continues to extend the lives of people with cancer, strategies for recording and managing their toxicity and long-term effects will need innovation too.
Microglial TDP-43 mediates myelin refinement and represses Tyrobp cryptic exon inclusion in mice
Nature Neuroscience, Published online: 08 July 2026; doi:10.1038/s41593-026-02348-3Compagnion et al. show that TDP-43 loss in microglia causes myelin defects, oligodendrocyte precursor cell imbalance and motor deficits in mice. They identify TDP-43 as a regulator of the TREM2-DAP12 signaling, through the…
Another big premium hike on the horizon
FDA's crackdown on online ketamine retailers, unprecedented health care premium hikes, and more health news from Morning Rounds
Opinion: STAT+: What’s the right role for AI in dementia care?
Three tricky questions about using AI in dementia care.
Millions of People in Canada Are Finding AI-Enabled Support for Mental Health Effective Amid Ongoing Questions Around Trust.
New national polling that is the first of its kind in Canada reveals a gap between the rapid adoption of AI tools for mental health support, effectiveness, and public distrust, pointing to human-centred design as the path forward. The post…
Opinion: The AI licensure debate is missing the point of licensure
“AI will reshape medicine. The physicians who answer for the outcome must lead the way it enters patient care," write Afnan R. Tariq and Ami Bhatt.
Are glucose monitors a good thing for 2-year-olds? Experts look at risks, benefits
The newly approved over-the-counter CGM offers a new approach to tackling childhood obesity but also raises a host of questions.
STAT+: Trump administration pursues more durable changes to science policy after setbacks in court
The White House has proposed sweeping changes to the bedrock regulation undergirding all federal contracts, empowering the executive branch to direct research, terminate grants, and external scientific reviews.
News Feed
Discharge Mobility After Osteoporotic Thoracolumbar Fractures Using a 2-Stage Machine Learning Prediction Model: Prospective Cohort Study
Background: Discharge mobility after osteoporotic vertebral fractures is heterogeneous and difficult to predict at admission. Machine learning offers structured approaches for multiclass functional outcome prediction, but existing models predominantly address binary end points and…
Single-Nucleus Multi-Omic Profiling Reveals Muscle Genetic Regulation Layer
Population-scale transcriptomics and chromatin accessibility profiling uncover thousands of disease-associated regulatory signals missed by transcriptomic analyses, raising questions about how many therapeutic targets are unknown. The post Single-Nucleus Multi-Omic Profiling Reveals Muscle Genetic Regulation…
Short-Term Low-Fat Diet Has Lasting Inflammatory Disease Benefits
Switching low-fat diet for just a few days at the onset of an inflammatory disease such as psoriasis could impact its trajectory in both the short and long term, according to a preclinical study.…
News
3069 results
Predictors of unfavorable 3-month functional outcome following intravenous thrombolysis with alteplase in anterior circulation acute ischemic stroke: a prospective cohort study
BackgroundIntravenous thrombolysis with alteplase remains the standard reperfusion strategy for acute ischemic stroke (AIS), yet many patients still experience unfavorable outcomes despite timely treatment, underscoring the need for reliable multimodal prognostic markers.ObjectiveTo identify independent clinical, laboratory, and neuroimaging predictors of…
Neonatal propofol exposure impairs synaptic plasticity and cognition, associated with BAG3 upregulation and disrupted synaptic protein homeostasis
BackgroundPropofol is widely used in pediatric anesthesia, but it has been implicated in adverse effects on brain development following repeated early-life exposure. Bag3, a co-chaperone protein involved in proteostasis and the neuronal stress response, may play a critical role in…
Integrated multi-omics and deep learning analysis reveals neurotransmitter metabolism regulatory mechanisms of Tianwang Buxin Dan
BackgroundTianwang Buxin Dan is a classical Traditional Chinese Medicine formula with documented clinical use in treating neuropsychiatric disorders, yet its molecular mechanisms remain incompletely understood.MethodsWe developed an integrated analytical framework combining transcriptomic and metabolomic profiling with deep learning to investigate…
Cerebrospinal fluid mechanics across CNS barriers: from production, circulation, and clearance to mechanomedicine
BackgroundCerebrospinal fluid (CSF) is often framed as a transport medium, yet its motion and pressure dynamics impose continuous mechanical loading on central nervous system (CNS) barrier and interface systems. These cues span scales—from cilia-scale near-wall shear to craniospinal compliance-driven pulsatility—and…
Automated diagnosis of Sturge–Weber syndrome by detecting leptomeningeal angiomatosis from MRI using a multi-task deep learning framework
ObjectivesSturge–Weber Syndrome (SWS) is a rare neurocutaneous disorder requiring early and accurate diagnosis. This study aims to develop a deep learning framework for automatic diagnosis of SWS by detecting leptomeningeal angiomatosis (LA) in brain magnetic resonance images (MRI).MethodsThis retrospective study…
Knowledge, attitudes, and perception toward new psychoactive substances among Saudi university students: a cross-sectional study
BackgroundNew psychoactive substances (NPS) are defined as chemical compounds that are synthesized or extracted from natural sources with the aim of producing psychoactive effects similar to those produced by controlled substances but not regulated under current legislation. Worldwide, the rise…
Increasing familial engagement in family violence services: a systematically conducted realist review of barriers and facilitators
PurposePhysical, emotional, and sexual violence and abuse occurring between close or extended family members are forms of family violence (FV). The negative impacts of FV are diverse, numerous, and pervasive for all individuals involved. To effectively support individuals experiencing FV,…
Power without limits: exploring emotional regulation, moral authority, and psychiatric overreach through the Wizarding World of Harry Potter
BackgroundPsychiatry has never had more tools to relieve psychological suffering. Psychopharmacology, neuromodulation, early intervention, digital monitoring, and preventive approaches have expanded what clinicians can do. Yet this growing technical capacity also raises an uneasy question: when does care become control?…
Memory-focused therapy: an integrated intervention to reduce trauma symptoms, maladaptive cognitive processes, and emotional distress in Afghan youth
BackgroundAfghan youth continue to face chronic war-related trauma, terrorist violence, and severe disruptions to education and social support systems, resulting in high rates of posttraumatic stress disorder (PTSD), depression, anxiety, and hopelessness. There is a critical need for culturally responsive,…
Parental broad autism phenotype traits and executive function in families of children with autism spectrum disorder
BackgroundParents of children with autism spectrum disorder (ASD) frequently exhibit subclinical Broad Autism Phenotype (BAP) traits, though their relationship with executive function (EF) remains underexplored. This study investigated associations between parental BAP traits and their EF performance.MethodsThe Broad Autism Phenotype…
An AAV vector for glial cells
Nature Biotechnology, Published online: 08 July 2026; doi:10.1038/s41587-026-03193-2Delivery of an in vivo–selected AAV into the glymphatics achieves broad transduction of human glial cells in chimeric mice.
Efficient targeting of human glial progenitor cells in vivo with engineered AAV vectors and glymphatic delivery
Nature Biotechnology, Published online: 08 July 2026; doi:10.1038/s41587-026-03185-2Viral vectors delivered through the brain glymphatics achieve widespread targeting of glial cells.
Oncology must confront hidden side effects
Nature Medicine, Published online: 08 July 2026; doi:10.1038/s41591-026-04554-9As a new generation of cancer drugs continues to extend the lives of people with cancer, strategies for recording and managing their toxicity and long-term effects will need innovation too.
Microglial TDP-43 mediates myelin refinement and represses Tyrobp cryptic exon inclusion in mice
Nature Neuroscience, Published online: 08 July 2026; doi:10.1038/s41593-026-02348-3Compagnion et al. show that TDP-43 loss in microglia causes myelin defects, oligodendrocyte precursor cell imbalance and motor deficits in mice. They identify TDP-43 as a regulator of the TREM2-DAP12 signaling, through the…
Another big premium hike on the horizon
FDA's crackdown on online ketamine retailers, unprecedented health care premium hikes, and more health news from Morning Rounds
Opinion: STAT+: What’s the right role for AI in dementia care?
Three tricky questions about using AI in dementia care.
Millions of People in Canada Are Finding AI-Enabled Support for Mental Health Effective Amid Ongoing Questions Around Trust.
New national polling that is the first of its kind in Canada reveals a gap between the rapid adoption of AI tools for mental health support, effectiveness, and public distrust, pointing to human-centred design as the path forward. The post…
Opinion: The AI licensure debate is missing the point of licensure
“AI will reshape medicine. The physicians who answer for the outcome must lead the way it enters patient care," write Afnan R. Tariq and Ami Bhatt.
Are glucose monitors a good thing for 2-year-olds? Experts look at risks, benefits
The newly approved over-the-counter CGM offers a new approach to tackling childhood obesity but also raises a host of questions.
STAT+: Trump administration pursues more durable changes to science policy after setbacks in court
The White House has proposed sweeping changes to the bedrock regulation undergirding all federal contracts, empowering the executive branch to direct research, terminate grants, and external scientific reviews.