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The Download: inside the Musk v. Altman trial, and AI for democracy
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Week one of the Musk v. Altman trial: what it was like in the room Two…
Frontotemporal dementia: does structural MRI-based clustering match clinical syndromes?
BackgroundFrontotemporal dementia is an umbrella term that encompasses several clinical syndromes with impaired behavioral, language, and motor functions. These syndromes show considerable overlap in clinical features and imaging patterns. Therefore, there is a need to investigate the syndromic heterogeneity in…
Evaluation of human body malodor using functional near-infrared spectroscopy with regions of interest based on functional pathways in the olfactory system
IntroductionMalodors in the human body can diminish comfort in living and working environments, potentially increasing stress and dissatisfaction levels. Therefore, there is a growing need to objectively characterize the properties of human body malodor. The brain extracts various types of…
Brief report: joint trajectories of anxiety and depression symptoms in an inception cohort of autistic youth
Background and AimsAnxiety and depression symptoms are common among autistic youth, yet little is known about the pattern and relationship of their trajectories from childhood into adolescence, a period of increasing social and academic demands.MethodsThis study used parallel process latent…
Impact of COVID-19 pandemic on autism spectrum disorder service providers in Qatar: challenges, insights, and lessons learned
PurposeThe COVID-19 pandemic disrupted essential services, posing unique challenges for individuals with Autism Spectrum Disorder (ASD) who depend on consistent, specialized support. Service providers faced unique challenges in adapting to remote delivery methods, highlighting the fragility of existing systems during…
Retrospective evaluation of transcranial magnetic stimulation for enhancing arousal in patients with minimally conscious state: a single-centre study in Inner Mongolia, China
ObjectiveThis study aimed to investigate the effect of high-frequency transcranial magnetic stimulation (TMS) targeting multiple brain regions on the recovery of consciousness in patients with minimally conscious state (MCS).MethodsA retrospective analysis was conducted on MCS patients between August 2022 and…
Effect of pharyngeal musculature and genioglossus exercising on obstructive sleep apnea-hypopnea syndrome following uvulopalatopharyngoplasty
ObjectiveThis study aimed to evaluate the effectiveness of pharyngeal musculature and genioglossus exercising as a postoperative rehabilitation intervention for patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) following uvulopalatopharyngoplasty (UPPP)—a setting with limited prior evidence.MethodsThis is a retrospective cohort study conducted…
Real-world use of brexpiprazole during inpatient treatment for schizophrenia: continuation, discontinuation, and concomitant psychotropics
IntroductionIn the treatment of schizophrenia, antipsychotics used during acute inpatient care must control acute symptoms while remaining sufficiently tolerable to support treatment beyond the acute phase. Brexpiprazole, a serotonin-dopamine activity modulator may be one such option; however, its real-world use…
Thymus renaissance poised to boost health and longevity
Nature Biotechnology, Published online: 05 May 2026; doi:10.1038/s41587-026-03137-wEvidence linking thymic function with health and longevity is piling up, and a cluster of biotechnology companies is trying to regenerate the thymus directly or recapitulate its function to reinvigorate patients’ immunity.
A single-cell screening platform accelerates functional genetics in plants
Nature Biotechnology, Published online: 05 May 2026; doi:10.1038/s41587-026-03094-4A pooled, cell-based, genetic screening platform in plants is used for the functional analysis of cytokinin signaling proteins.
Multinational validation of the PREVENT and SCORE2 cardiovascular risk equations across 6.4 million individuals
Nature Medicine, Published online: 05 May 2026; doi:10.1038/s41591-026-04437-zComprehensive, multinational validation of the PREVENT and SCORE2 cardiovascular risk scores, used in the United States and Europe, respectively, in 44 observational studies and 18 randomized trials, shows similar performance for the two…
Risk for Autism Across Generations
Autism spectrum disorder (ASD) has a complex inheritance pattern and is more common in males. Etiological models suggest that majority of ASD risk is transmitted through common and rare de-novo genetic variation. It has been hypothesized that rare variation could…
Astrocytic cholesterol jams brain clearance in AD
Nature Neuroscience, Published online: 05 May 2026; doi:10.1038/s41593-026-02310-3Zhang and colleagues identify astrocytic calcium–cholesterol–AQP4 signaling that drives glymphatic dysfunction in early Alzheimer’s disease (AD). Attenuating this signaling restored glymphatic flow, reduced amyloid burden and improved cognition in young 5xFAD mice only…
Molecular mechanism of calcium permeability and magnesium block in NMDA receptors
Nature Neuroscience, Published online: 05 May 2026; doi:10.1038/s41593-026-02283-3Using cryo-electron microscopy and electrophysiology, this study explains the structural basis for Ca2+ permeation and Mg2+ block in NMDA receptors and identifies a surrounding lipid network that may tune Mg2+-dependent voltage sensitivity.
What you need to know about hantavirus (don’t panic)
The latest on the abortion pill, paternal deaths, and more health news from Morning Rounds
STAT+: Cytokinetics drug Myqorzo meets twin efficacy goals in study of genetic heart disease
A Cytokinetics heart disease drug — already approved in one indication — succeeded in another Phase 3 trial, a potential boost for sales.
A blueprint for using AI to strengthen democracy
Every few centuries, changes in how information moves reshape how societies govern themselves. The printing press spread vernacular literacy, helping give rise to the Reformation and, eventually, representative government. The telegraph made it possible to administer vast nations like the…
Opinion: The ‘brain drain’ narrative about health professionals misses half of the story
52 health professionals returned home to 43 countries. Here are the unexpected challenges and opportunities they faced.
Opinion: The cruise ship hantavirus outbreak is a warning sign to the U.S.
Leaving the WHO means the U.S. lacks access to necessary information about infectious disease.
STAT+: Top lawmaker takes aim at doctor lobby, linking AMA’s billing codes to fraud fight
A top Republican is asking if the AMA's codes are helping to fuel health care fraud.