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New national action plan targets gaps at the intersection of mental health and criminal justice.
FOR IMMEDIATE RELEASE OTTAWA, ON – The Mental Health Commission of Canada (the Commission) today released “Finding New Pathways: An action plan for criminal justice and mental health in Canada”. The plan provides an evidence-based…
Kinase Droplets Activate Growth Signals, Path for Cancer Therapy
Cellular phase separation, a mechanism that organizes biomolecules into dense, liquid-like condensates, may play a previously underappreciated role in regulating kinase activity, offering therapeutic applications. The post Kinase Droplets Activate Growth Signals, Path for Cancer Therapy…
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Genomic approaches for understanding the evolution of the human brain
Nature Neuroscience, Published online: 21 April 2026; doi:10.1038/s41593-026-02277-1This Review describes how an approach that starts from genetic changes under selection during human evolution and integrates comparative and functional studies can reveal adaptive phenotypes across different evolutionary timescales.
Constituent-constrained word prediction during language comprehension
Nature Neuroscience, Published online: 21 April 2026; doi:10.1038/s41593-026-02272-6Zou et al. reveal a key difference between human brains and large language models (LLMs). While LLMs are optimized to predict the next word, the human brain modulates prediction efficiency by strategically grouping…
STAT+: Tortugas Neuroscience launches with hopes to develop drugs for brain disorders, other conditions
Tortugas Neuroscience launched Tuesday with plans to develop drugs licensed from Chinese drugmaker Jiangsu Hansoh and Japanese pharmaceutical Eisai.
STAT+: BioAge says experimental pill aimed at reducing heart risks significantly reduced inflammation
BioAge Labs said its investigational pill for cardiovascular risk prevention significantly reduced inflammation in an early study.
Digging for clues about the North Pole’s past
In the past, even with an icebreaker and during peak melt season, getting to the North Pole wasn’t a sure bet. It took favorable winds to crack the frozen ocean surface, and ships had to fight through ice that had…
Opinion: The U.S. health care system is built around looking backward
A reconstruction layer has fallen on medicine. It asks: Was the original decision justified?
Opinion: What happens when a chief executive loses executive functions?
When a CEO develops acquired executive dysfunction yet remains in their role, the challenges are significant.
Transcranial Photobiomodulation (tPBM) for Somatic Symptoms in Treatment-Resistant Depression
Conditions: Treatment-resistant Depression (TRD); Major Depression Disorder Interventions: Device: transcranial photobiomodulation Sponsors: Taipei Veterans General Hospital, Taiwan Recruiting
Pilot Randomized Trial of BA-GSH in VA PC-MHI
Conditions: Depression Interventions: Behavioral: Behavioral Activation-Guided Self-Help Sponsors: VA Office of Research and Development Not yet recruiting
MDMA Assisted Therapy for BN
Conditions: Bulimia Nervosa Interventions: Drug: MDMA-AT; Drug: MDMA-AT-BN; Behavioral: Standard Treatment (ST) Sponsors: Icahn School of Medicine at Mount Sinai Not yet recruiting
Adapting Behavioral Interventions for Dementia to Address NCDs and Mental Health
Conditions: Mental Health; Non Communicable Diseases; Dementia Interventions: Behavioral: BECOME-D Intervention Sponsors: Possible; University of California, San Francisco; National Institute of Mental Health (NIMH); Ministry of Health and Population, Nepal Completed
Photobiomodulation on Core Symptoms of Autism
Conditions: Autism Interventions: Device: Photobiomodulation Sponsors: Suez University Not yet recruiting
Policy implications for halting human trafficking and sexual exploitation at U.S. colleges and universities: results from a 12-campus survey
Human trafficking is a priority concern in the U.S, but few research studies have investigated the nature and extent of its occurrence on U.S. college campuses nor strategies to stop it. The objective of this research was to identify its…
Cibisatamab and FAP-4-1BBL in microsatellite-stable colorectal cancer: a phase 1b trial
Nature Medicine, Published online: 20 April 2026; doi:10.1038/s41591-026-04380-zAs presented at the 2026 AACR Annual Meeting: in a phase 1b trial, patients with microsatellite-stable colorectal cancer received a FAP-4-1BB ligand together with the CEA-directed T cell engager cibisatamab; the treatment was…
Ciltacabtagene autoleucel in high-risk smoldering multiple myeloma: the CAR-PRISM phase 2 trial
Nature Medicine, Published online: 20 April 2026; doi:10.1038/s41591-026-04365-yAs presented at the 2026 AACR Annual Meeting, in a phase 2 trial, treatment of patients with high-risk smoldering multiple myeloma with BCMA-targeting CAR T cell therapy ciltacabtagene autoleucel was safe and led…
Microbiome signature of Parkinson’s disease in healthy and genetically at-risk individuals
Nature Medicine, Published online: 20 April 2026; doi:10.1038/s41591-026-04318-5Microbiome analysis suggests that gut microbial changes in Parkinson’s disease evolve progressively from healthy individuals to genetically at-risk individuals to clinically affected patients, with the degree of dysbiosis correlating with disease progression.
STAT+: At AACR, a provocative use of CAR-T, Merck’s new thing and cancer’s geography problem
At AACR, a bold use of CAR-T raises hopes and provocative questions about its use in smoldering multiple myeloma.
STAT+: Former banker brought on to revitalize Pfizer’s strategy departs his post
Andrew Baum, a former Citi analyst, has left his role as Pfizer's executive vice president and chief strategy and innovation officer.
Access to Technology-Mediated Community Mental Health Care Among Low-Socioeconomic Status Consumers With Serious Mental Illness: Qualitative Study
Background: Access to mental health care is critical for the effective management of serious mental illness (SMI), but consumers with low socioeconomic status (SES) have lower rates of service usage and worse retention in care. Digital technologies are often lauded…
STAT+: In early trial, CAR-T results raise hope of preventing multiple myeloma in high-risk patients
A CAR-T trial shows promise in preventing smoldering multiple myeloma from becoming the real thing.