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New national action plan targets gaps at the intersection of mental health and criminal justice.
FOR IMMEDIATE RELEASE OTTAWA, ON – The Mental Health Commission of Canada (the Commission) today released “Finding New Pathways: An action plan for criminal justice and mental health in Canada”. The plan provides an evidence-based…
Kinase Droplets Activate Growth Signals, Path for Cancer Therapy
Cellular phase separation, a mechanism that organizes biomolecules into dense, liquid-like condensates, may play a previously underappreciated role in regulating kinase activity, offering therapeutic applications. The post Kinase Droplets Activate Growth Signals, Path for Cancer Therapy…
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Opportunities for Digital Health to Support Early Psychosis Care in Ghana: Qualitative Study Among Patients, Caregivers, and Clinicians
Background: Youth experiencing early psychosis in West Africa often face delays in accessing evidence-based treatment. Digital mental health interventions may offer an acceptable and scalable approach to improve access to early psychosis care in West Africa; however, few data exist…
Popular Online Content as a Treatment-as-Usual Control in Digital Mental Health Intervention Trials: Secondary Analysis of Two Online Randomized Controlled Trials With Repeated Measures
Background: Treatment-as-usual (TAU) conditions are intended to reflect the support typically received in routine treatment settings. For digital mental health interventions (DMHIs) delivered online, TAU conditions should reflect the usual patterns of online help-seeking. The lack of ecologically valid TAU…
STAT+: Trump order to advance psychedelic treatments generates excitement — and worries
President Trump’s executive order on was largely applauded by advocates. But some also quietly worried the White House’s role risks politicizing their field and undermining its credibility.
Opinion: The contradiction at the heart of Republicans’ embrace of psychedelics
“The research is clear about one thing: Recovery is not primarily a pharmacological event,” write Dimitri Mugianis and Ross Ellenhorn.
The Download: murderous ‘mirror’ bacteria, and Chinese workers fighting AI doubles
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. No one’s sure if synthetic mirror life will kill us all In February 2019, a group…
Short-term intrinsic connectivity changes induced by cognitive exertion in healthy participants
IntroductionChanges in brain intrinsic connectivity on the timescale of minutes, as provoked by a cognitive task, have not been well documented.MethodsA total of two 7.5-min 7 Tesla functional MRI (fMRI) scans (Run 1 and Run 2), separated by 90 s, were…
Altered static and dynamic regional homogeneity in basal ganglia–thalamocortical circuits and their association with neuropsychiatric manifestations in Wilson’s disease
PurposeWilson’s disease (WD) is an autosomal recessive disorder caused by ATP7B mutations, resulting in impaired copper metabolism and progressive neuropsychiatric manifestations. This study investigated spatiotemporal alterations in regional brain activity using static and dynamic resting-state fMRI with regional homogeneity (ReHo),…
Neurobiological effects of microbial treatments within psychiatry: a systematic review
ObjectiveThough microbial interventions such as probiotics and fecal microbiota transplantation have had a growing body of evidence suggesting their efficacy in alleviating the symptoms of psychiatric illnesses, their exact mechanisms of action and impacts on the brain are still not…
Electrocardiographic findings in children and adolescents treated with antipsychotics: a cohort study
Background/objectivesAntipsychotic drugs are increasingly prescribed in children and adolescents across a wide range of psychiatric conditions. Although cardiovascular adverse effects are generally considered uncommon, concerns about electrocardiographic abnormalities, particularly QTc interval prolongation, have led to ongoing debate regarding appropriate monitoring…
Postmarketing surveillance of elobixibat for patients with chronic constipation and concomitant schizophrenia or depression in Japan
BackgroundLittle is known about the optimal treatment for constipation in patients with schizophrenia or depression. Elobixibat is a laxative with a novel mechanism of action that inhibits the ileal bile acid transporter, acting as both an osmotic and a stimulant…
Twelve-month outcomes and comparative costs of internet-delivered psychodynamic therapy versus cognitive-behavioral therapy for adolescent depression: a randomized controlled trial
IntroductionAdolescent depression poses a major public health concern with substantial clinical and societal implications. Both internet-delivered cognitive behavioural therapy (ICBT) and internet-delivered psychodynamic therapy (IPDT) have shown efficacy, but questions remain regarding long-term efficacy and cost-effectiveness. The present study presents…
Machine learning for oral frailty factors in hospitalized schizophrenia patients: two-stage feature selection and SHAP analysis
BackgroundLong-term hospitalized patients with schizophrenia (SZ) often experience significant oral health problems, and oral frailty (OF) can further exacerbate the decline in their quality of life. However, the status and key influencing factors contributing to OF in this population remain…
Comprehensive profiling of clinically approved kinase inhibitors reveals mutation-specific inhibitors and opportunities for drug repurposing
Nature Biotechnology, Published online: 20 April 2026; doi:10.1038/s41587-026-03090-8A large screen of approved kinase inhibitors expands the druggable kinome.
How weed affects adolescent brains
The latest CDC director nominee, the ongoing measles outbreak, and other health news from Morning Rounds
STAT+: Extended use of Nektar Therapeutics drug shows promise in alopecia
Extended use of a drug from Nektar Therapeutics promoted hair growth in people with alopecia.
Colossal Biosciences said it cloned red wolves. Is it for real?
If you want to capture something wolflike, it’s best to embark before dawn. So on a morning this January, with the eastern horizon still pink-hued, I drove with two young scientists into a blanket of fog. Forty miles to the…
Chinese tech workers are starting to train their AI doubles–and pushing back
Tech workers in China are being instructed by their bosses to train AI agents to replace them—and it’s prompting a wave of soul-searching among otherwise enthusiastic early adopters. Earlier this month a GitHub project called Colleague Skill, which claimed workers…