News Feed
New national action plan targets gaps at the intersection of mental health and criminal justice.
FOR IMMEDIATE RELEASE OTTAWA, ON – The Mental Health Commission of Canada (the Commission) today released “Finding New Pathways: An action plan for criminal justice and mental health in Canada”. The plan provides an evidence-based…
Kinase Droplets Activate Growth Signals, Path for Cancer Therapy
Cellular phase separation, a mechanism that organizes biomolecules into dense, liquid-like condensates, may play a previously underappreciated role in regulating kinase activity, offering therapeutic applications. The post Kinase Droplets Activate Growth Signals, Path for Cancer Therapy…
News
1477 results
STAT+: Kennedy focuses on affordability, combating fraud in Capitol Hill hearings
RFK Jr. focused on President Trump's health care agenda and largely avoided vaccines.
STAT+: Researchers behind GLP-1 obesity drugs advance new approach: Drop GLP-1 as a target
Scientists are raising a provocative hypothesis about GLP-1 drugs for obesity: Perhaps targeting the GLP-1 hormone isn't actually necessary to achieve effective weight loss.
Treating enterprise AI as an operating layer
There’s a fault line running through enterprise AI, and it’s not the one getting the most attention. The public conversation still tracks foundation models and benchmarks—GPT versus Gemini, reasoning scores, and marginal capability gains. But in practice, the more durable…
Making AI operational in constrained public sector environments
The AI boom has hit across industries, and public sector organizations are facing pressure to accelerate adoption. At the same time, government institutions face distinct constraints around security, governance, and operations that set them apart from their business counterparts. For…
The Download: cyberscammers’ banking bypasses, and carbon removal troubles
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Cyberscammers are bypassing banks’ security with illicit tools sold on Telegram Inside a money-laundering center in Cambodia, an employee…
Spatial evolution in temporal dynamics of hemodynamic response function in human superior colliculi with ultra-high-resolution MRI at 9.4T
The superior colliculus (SC) plays a crucial role in multisensory integration, visual information processing, saccadic target selection, visual selective attention, and decision making. In particular, the SC has a key role in oculomotor coordination, following a rostro-caudal organization. The rostral…
MambaSSM: efficient segmentation of brain structures in anisotropic 3D EM images via state-space models
Accurate segmentation of brain structures from anisotropic 3D electron microscopy (EM) images remains challenging due to the trade-off between global context modeling and computational efficiency. While state-space models (SSMs) like Mamba have shown promise in capturing long-range dependencies, their direct…
Role of TRPC1 in the pathogenesis of depression induced by traumatic brain injury
BackgroundTraumatic brain injury (TBI) is one of the leading causes of mortality and disability, with many patients developing long-term sequelae. Depression is among the most common psychiatric complications following TBI, yet its underlying mechanisms remain unclear. Transient receptor potential canonical…
Diffusion tensor imaging-functional MRI fusion reveals disrupted white matter structure–function coupling in HIV-associated asymptomatic neurocognitive impairment
ObjectiveConventionally, blood oxygen level-dependent (BOLD) signals derived from resting-state functional magnetic resonance imaging (rs-fMRI) are attributed to gray matter, but recent evidence confirms stable low-frequency oscillations within white matter. While structure–function coupling is pivotal in neuropsychiatry, it remains underexplored in…
The relationship between impulsivity and non-suicidal self-injury in adolescents: the chain-mediated effects of parenting style and distress tolerance
ObjectiveThe purpose of this study is to explore the related risk factors and protective factors of adolescent non suicidal self injury (NSSI).MethodsUtilizing the experience sampling method, we recruited 311 adolescents engaging in NSSI, all without other mental disorders, from five…
Research progress on social participation of young and middle-aged stroke survivors: a narrative review
Stroke is characterized by high morbidity, disability, and mortality, and has become the third leading cause of death worldwide. In China, stroke accounts for 39.9% of all cerebrovascular diseases, with young and middle-aged survivors (aged 40–60 years) comprising 33% of…
A qualitative study on the participation experience in a mental health recovery program based on WHO QualityRights in South Korea
IntroductionThe World Health Organization’s QualityRights initiative offers a practical framework for developing rights-based, person-centered, and recovery-oriented mental health systems. In Korea, the face-to-face WHO QualityRights specialized training module, Recovery practices for mental health and well-being, was culturally and clinically adapted…
Protocol for a randomized trial to predict the efficacy of cognitive and behavioral interventions for symptoms of depression
IntroductionCognitive behavioral therapy (CBT) is one of the most common interventions for depression and has two key components: Cognitive Restructuring (CR) and Behavioral Activation (BA). However, no evidence-based guidelines exist to help clients and clinicians decide whether CBT would be…
Empathy and alexithymia in essential tremor
BackgroundSocial cognition is increasingly recognized as part of the non-motor phenotype of essential tremor (ET). Available ET evidence suggests selective alterations in some socio-cognitive domains, whereas findings on self-reported empathy and alexithymia remain limited and inconsistent.ObjectivesThis cross-sectional study aimed to…
Sequencing peptides by reversing translation
Nature Biotechnology, Published online: 16 April 2026; doi:10.1038/s41587-026-03108-1A new peptide sequencing approach converts amino acids into DNA sequences, which are easily read.
Diversity-generating retroelements for programmable targeted hypermutagenesis
Nature Biotechnology, Published online: 16 April 2026; doi:10.1038/s41587-026-03078-4Diversity-generating retroelements are engineered for directed evolution in E.coli.
Trabectedin and low-dose irinotecan to target EWS::FLI1 in Ewing sarcoma: a phase 1/2 trial
Nature Medicine, Published online: 16 April 2026; doi:10.1038/s41591-026-04340-7In this phase 1/2 trial, patients with Ewing sarcoma received trabectedin and low-dose irinotecan at concentrations known to inhibit the activity of the transcription factor EWS::FLI1, leading to encouraging clinical response rates.
Integrated epidemiological and molecular data inform the relationship between precancer and cancer states of esophageal adenocarcinoma
Nature Medicine, Published online: 16 April 2026; doi:10.1038/s41591-026-04331-8Analyses of epidemiological, clinical and molecular data from a prospective cohort of 3,100 patients with esophageal carcinoma suggest intestinal metaplasia as a single precancer pathway preceding the disease.