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New national action plan targets gaps at the intersection of mental health and criminal justice.
FOR IMMEDIATE RELEASE OTTAWA, ON – The Mental Health Commission of Canada (the Commission) today released “Finding New Pathways: An action plan for criminal justice and mental health in Canada”. The plan provides an evidence-based…
Kinase Droplets Activate Growth Signals, Path for Cancer Therapy
Cellular phase separation, a mechanism that organizes biomolecules into dense, liquid-like condensates, may play a previously underappreciated role in regulating kinase activity, offering therapeutic applications. The post Kinase Droplets Activate Growth Signals, Path for Cancer Therapy…
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Spatial and single-cell characterization of human glioblastoma tumor microenvironment reveals malignant cellular communities
Nature Neuroscience, Published online: 16 April 2026; doi:10.1038/s41593-026-02265-5Integrating spatial and single-cell data from 100 patients, the authors define conserved cellular communities and communications in glioblastoma, revealing distinct mesenchymal-like tumor subtypes and predominant neurogliomal synapses that shape tumor progression.
Spatial, temporal and Notch determination of terminal selector expression controls neuronal cell fate in the Drosophila optic lobe
Nature Neuroscience, Published online: 16 April 2026; doi:10.1038/s41593-026-02256-6The authors characterized the spatial origin of Drosophila medulla neurons, completing their previous characterization of the temporal and Notch origins of these neurons and allowing them to correlate patterning of progenitors and neuronal…
The mental health parity gap is gaping
RFK Jr.'s testimony to Congress, broader access to peptides, and more health news from Morning Rounds
STAT+: Roche to launch another Elevidys trial, with eyes on European approval
Roche is launching a Phase 3 trial of the controversial Duchenne gene therapy Elevidys, hoping it could lead to approval in Europe.
STAT+: Travere’s drug for a kidney disease doesn’t improve kidney function. The FDA approved it anyway
How a rare disease drugmaker won FDA approval after a clinical trial disappointed.
STAT+: 7 key issues we’re watching as RFK Jr. faces a Congressional gauntlet
RFK Jr. has a delicate task ahead of him as he faces a marathon of hearings on Capitol Hill.
Is carbon removal in trouble?
Last week, news outlets reported that Microsoft was pausing carbon removal purchases. It was something of a bombshell. The thing is, Microsoft is the carbon removal market. The company has single-handedly purchased something like 80% of all contracted carbon removal.…
The quest to measure our relationship with nature
As a movement, environmentalism has been pretty misanthropic. Understandably so—we humans have done some destructive things to the ecosystems around us. In the 21st century, though, mainstream conservation is learning that humans can be a force for good. Foresters are…
The noise we make is hurting animals. Can we learn to shut up?
When the covid-19 pandemic started, Jennifer Phillips thought about the songs of the sparrows. They were easier to hear, because the world had suddenly become quieter. Car traffic plummeted as people sheltered at home and shifted to remote work. Air…
Opinion: STAT+: The medical AI revolution requires rethinking health care’s architecture
"Instead of organizing health data around institutions, we might organize it around individuals," write Meta's Freddy Abnousi and Stanford's Celina Yong.
Venous Tourniquet vs. Arterial Tourniquet for Seizure Monitoring in ECT
Conditions: Major Depressive Disorder; Bipolar Disorder; Schizophrenia Interventions: Device: Device: Arterial Tourniquet; Device: Device: Venous Tourniquet Sponsors: Medipol University Not yet recruiting
AI-Assisted 4-Week Psychodynamic Therapy and Cognitive Behavioral Therapy Via Smartphone for Social Anxiety: A Randomized Pilot Study (STePS-Ai)
Conditions: Social Anxiety Disorder (SAD) Interventions: Behavioral: Ai chatbot Sponsors: Stockholm University Active, not recruiting
The Download: NASA’s nuclear spacecraft and unveiling our AI 10
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. NASA is building the first nuclear reactor-powered interplanetary spacecraft. How will it work? Just before Artemis…
An inducible base editing platform for cancer functional genomics in vivo
Nature Biotechnology, Published online: 15 April 2026; doi:10.1038/s41587-026-03079-3We developed a functional genomics platform using a small-molecule-controllable base editor that enables gene editing with reduced cellular toxicity and minimal transcriptional perturbation. The resulting high efficiency of the method potentiates in vivo…
Can psychiatric genetics advance without incorporating a lifecourse perspective?
Psychiatric disorders unfold over the lifecourse, yet genomic studies of these conditions overwhelmingly rely on phenotypes collected at a single time point, often in adulthood. Genome-wide association studies (GWAS) of psychiatric conditions may therefore miss genetic variants with time-varied relevance…
Baseline Mismatch Negativity Amplitude Predicts Direction and Magnitude of Ketamine Effect in Healthy Volunteers — A “Disordinal” Effect
Mismatch negativity (MMN) is a component of the auditory event-related potential (ERP) that is elicited during a passive oddball paradigm where task-irrelevant infrequent deviants are presented in a stream of more frequent standard stimuli. MMN is believed to index a…
[Comment] Assessing adolescents’ use of artificial intelligence in psychiatric practice
In a recent clinical encounter with one of the authors (AP), a young boy with autism insisted that his mother hated him—because ChatGPT said so. After asking whether a parent who sets limits must dislike their child, he interpreted the…
[Comment] Youth mental health in central Asia: research needs
Little research has been published on mental health difficulties in young people (aged 10–24 years) living in central Asia,1 a region comprising Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan. As researchers and representatives from academic, non-governmental, governmental, and UN organisations working…
[Comment] Magnetic seizure therapy: balancing efficacy and cognition
Few treatments in psychiatry match the antidepressant efficacy of convulsive therapy. Yet despite this therapeutic potency, persistent stigma and concerns about cognitive adverse effects—particularly autobiographical memory disturbance associated with electroconvulsive therapy, ECT—continue to limit its wider adoption.1 This tension is…
Determinants of Digital Health Literacy Among Patients With Serious Mental Illness: Cross-Sectional Survey
Background: Individuals with serious mental illness increasingly use digital devices and the internet to access health information and services but often face challenges when navigating digital tools, which may limit the benefits they receive from online health resources and digital…