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Expression of Concern for: Nicotine breaks down preformed Alzheimer’s β-amyloid fibrils in vitro
Expression of Concern for: “Nicotine breaks down preformed Alzheimer’s β-amyloid fibrils in vitro,” by Ono et al. (Biol Psychiatry 2002; 52:880–886); https://doi.org/10.1016/S0006-3223(02)01417-8.
Opinion: The podcast bringing together MAHA and public health for hard conversations
“These sides aren't talking to each other. And there's a lot riding on it”: The hosts of “Why Should I Trust You?” on bringing together MAHA and public health.
Optimism for Trump’s CDC pick is tempered by questions about RFK Jr.’s role
As one CDC employee, who asked not to be named, put it on Friday, among staff “the general vibe is guarded but hopeful.”
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Opinion: STAT+: The medical AI revolution requires rethinking health care’s architecture
"Instead of organizing health data around institutions, we might organize it around individuals," write Meta's Freddy Abnousi and Stanford's Celina Yong.
Venous Tourniquet vs. Arterial Tourniquet for Seizure Monitoring in ECT
Conditions: Major Depressive Disorder; Bipolar Disorder; Schizophrenia Interventions: Device: Device: Arterial Tourniquet; Device: Device: Venous Tourniquet Sponsors: Medipol University Not yet recruiting
AI-Assisted 4-Week Psychodynamic Therapy and Cognitive Behavioral Therapy Via Smartphone for Social Anxiety: A Randomized Pilot Study (STePS-Ai)
Conditions: Social Anxiety Disorder (SAD) Interventions: Behavioral: Ai chatbot Sponsors: Stockholm University Active, not recruiting
The Download: NASA’s nuclear spacecraft and unveiling our AI 10
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. NASA is building the first nuclear reactor-powered interplanetary spacecraft. How will it work? Just before Artemis…
An inducible base editing platform for cancer functional genomics in vivo
Nature Biotechnology, Published online: 15 April 2026; doi:10.1038/s41587-026-03079-3We developed a functional genomics platform using a small-molecule-controllable base editor that enables gene editing with reduced cellular toxicity and minimal transcriptional perturbation. The resulting high efficiency of the method potentiates in vivo…
Can psychiatric genetics advance without incorporating a lifecourse perspective?
Psychiatric disorders unfold over the lifecourse, yet genomic studies of these conditions overwhelmingly rely on phenotypes collected at a single time point, often in adulthood. Genome-wide association studies (GWAS) of psychiatric conditions may therefore miss genetic variants with time-varied relevance…
Baseline Mismatch Negativity Amplitude Predicts Direction and Magnitude of Ketamine Effect in Healthy Volunteers — A “Disordinal” Effect
Mismatch negativity (MMN) is a component of the auditory event-related potential (ERP) that is elicited during a passive oddball paradigm where task-irrelevant infrequent deviants are presented in a stream of more frequent standard stimuli. MMN is believed to index a…
[Comment] Assessing adolescents’ use of artificial intelligence in psychiatric practice
In a recent clinical encounter with one of the authors (AP), a young boy with autism insisted that his mother hated him—because ChatGPT said so. After asking whether a parent who sets limits must dislike their child, he interpreted the…
[Comment] Youth mental health in central Asia: research needs
Little research has been published on mental health difficulties in young people (aged 10–24 years) living in central Asia,1 a region comprising Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan. As researchers and representatives from academic, non-governmental, governmental, and UN organisations working…
[Comment] Magnetic seizure therapy: balancing efficacy and cognition
Few treatments in psychiatry match the antidepressant efficacy of convulsive therapy. Yet despite this therapeutic potency, persistent stigma and concerns about cognitive adverse effects—particularly autobiographical memory disturbance associated with electroconvulsive therapy, ECT—continue to limit its wider adoption.1 This tension is…
Determinants of Digital Health Literacy Among Patients With Serious Mental Illness: Cross-Sectional Survey
Background: Individuals with serious mental illness increasingly use digital devices and the internet to access health information and services but often face challenges when navigating digital tools, which may limit the benefits they receive from online health resources and digital…
STAT+: CMS proposes rolling back breakthrough device payment flexibilities
CMS is proposing to repeal a pathway that allows breakthrough devices to get supplementary payments.
Motoneurons Inhibitory Synapses Homeostatically Respond to Neuronal Activity and Modulate Amyotrophic Lateral Sclerosis Pathogenesis
Alterations in excitation/inhibition (E/I) balance and changes in motor neurons (MN) activity may contribute to MN vulnerability in ALS. The balance of pathogenic versus adaptive changes occurring in inhibitory synapses and affecting E/I balance remain unclear. Confocal microscopy of MN…
Development of a Contextualized, Research-Based Flemish Assessment Framework for Digital Care, Assistance, and Support: Delphi Study
Background: The rapid evolution of digital technologies has transformed health, mental health, and social care, offering new modalities of digital care, assistance, and support through web-based platforms, mobile apps, extended reality, wearables, and artificial intelligence systems. Despite this proliferation, there…
STAT+: Novartis CEO joins Anthropic’s board
Revolution Medicines $2B fundraise, Structure's new hire hints at acquisition efforts, and more Readout biotech news
STAT+: FDA panel will meet to discuss allowing broader access to certain peptides
The FDA will convene an outside panel of advisers to discuss whether to allow compounding pharmacies to manufacture certain peptides
STAT+: A $15 AI test, Project Glasswing, and how Doctronic pilot blindsided Utah medical board
In this edition of STAT's AI Prognosis: A $15 AI test, what Project Glasswing means for health care, and an update on Doctronic's AI pilot in Utah.
STAT+: Pharmalittle: We’re reading about FDA seeking more data on a Lilly obesity pill, a pharma 340B win, and more
The FDA asked Eli Lilly for more data on liver injury linked to its newly approved obesity pill, Foundayo
Aberrant local and global neural activation patterns in pediatric Prader–Willi syndrome
PurposeAlthough cognitive disorders in children with Prader–Willi syndrome (PWS) are linked to abnormalities in spontaneous neural activation and functional connectivity (FC), the specific neural activation patterns remain uncertain, especially in young children with PWS.MethodsThe current study set out to explore…