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King’s pilots digital prehab for hip and knee replacement patients
King’s College Hospital NHS Foundation Trust has launched a digital prehab trial for patients awaiting hip and knee replacement surgery.
Merck, Protillion Launch AI Drug Discovery Collaboration with Up-to-$510M in Milestone Payments
The collaboration, launched through a multi-target discovery collaboration and license agreement, is designed to combine Merck’s global expertise in discovering novel therapeutics with Protillion’s Prot-MaP™ on-chip antibody discovery platform, short for Protein Display on…
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RFK Jr. claims his calendar is publicly available. We’ve been trying to get it for a year
None of STAT's requests for Kennedy's schedule have been completed, and some haven't even been acknowledged.
Drinking during pregnancy rose after 2020, new CDC data suggest
A new CDC report underscores that drinking during pregnancy, while generally thought of as a thing of the past, is still a matter of concern.
STAT+: AMA and lawmakers push back on AI care denials
In this edition of STAT Health Tech: HHS watchdog on denials by health insurers, lawmakers target AI denials, and Talkspace's new chatbot offering.
Examining the Social and Mental Health Benefits of Virtual and In-Person Physical Activity Intervention Among Postsecondary Students: Quasi-Experimental Study
Background: Physical activity (PA) is a promising prevention approach for supporting mental health and enhancing social inclusion among postsecondary students. However, it is unclear whether similar outcomes are realized when PA programming is delivered in-person versus virtually. Objective: Using data…
Nonprofit buys experimental cancer drug to maintain patient access
In a rare move, nonprofit organization Blood Cancer United is buying the remaining supplies of a discontinued investigational cancer drug.
Higher Vitamin C Levels in Blood Linked to Healthier Aging Brains
Older adults with higher blood levels of vitamin C have a higher volume of gray matter in their brains and higher connectivity across brain regions involved in memory and attention. The post Higher Vitamin C Levels in Blood Linked to…
Potential Cocaine Addiction Targets Identified Through Genetic Mapping in Rats
A GWAS carried out in a genetically diverse population of rats identified genetic markers associated with compulsive cocaine use, and uncovered a potential new therapeutic target in the liver. The post Potential Cocaine Addiction Targets Identified Through Genetic Mapping in…
App-Based Physical Activity Intervention for Individuals With Depression (MoodMover): Single-Arm, Pre-Post Proof-of-Concept and Feasibility Study
Background: Depression is a prevalent mental disorder, and it remains one of the leading causes of disability in Canada and globally. Mobile app–based physical activity interventions may offer an effective and accessible treatment option for individuals with depression who cannot…
A Self-Guided Web-Based Transdiagnostic Mental Health Program for People With Intellectual Disability: Single-Arm Trial
Background: People with intellectual disability experience rates of mental illness up to 3 times higher than the general population, yet face significant barriers to care, including limited clinician expertise, diagnostic overshadowing, and exclusion from key mental health services. Electronic mental…
Between Help and Harm: An Evaluation Study of Mental Health Crisis Handling by Large Language Models
Background: The use of large language models (LLMs)–powered chatbots has reshaped how people seek information and advice, including for emotional and mental health support. While LLMs can offer scalable support, their ability to safely detect and respond to acute mental…
The Download: soccer’s data renaissance and China’s big nuclear plans
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Inside soccer’s data renaissance Imagine tuning in to the opening kickoff of a World Cup match…
The exercise-microbiota-queuine-tRNA axis in Parkinson’s disease: evidence, uncertainties, and experimental priorities
Parkinson's disease (PD) is a multisystem neurodegenerative disorder characterized by progressive nigrostriatal dopaminergic degeneration, α-synuclein aggregation, mitochondrial dysfunction, oxidative stress, and neuroinflammatory remodeling. Although these mechanisms have been extensively investigated, how systemic metabolic and microbiota-derived signals intersect with neuronal translational…
Occipital and parietal non-invasive brain stimulation enhances perceptual learning and transfer: evidence from high-frequency tRNS
Perceptual training yields specific, long-lasting improvements, yet its transfer to untrained conditions is often limited. This tension has been proposed to involve interactions between early sensory plasticity and higher-order parietal processes, with the early visual cortex contributing to stimulus-specific learning…
Neural and autonomic regulation during brief mindfulness and relaxation interventions in clinical populations: a multimodal MEG study protocol
Mental disorders pose a major and growing challenge for health care systems worldwide, marked by persistent treatment gaps and limited access to psychotherapeutic care. Mind–body interventions such as mindfulness and relaxation practices are widely used in clinical contexts as low-threshold…
Do stretch sensors expressed by aortic baroreceptors interact with circulating estradiol to mediate baroreflex sensitivity in hypertension?
Hypertension, or high blood pressure, is a major risk factor for cardiovascular disease, the leading cause of mortality worldwide. The incidence and the severity of hypertension is higher in middle-aged men than women. The hallmark of hypertension is an increased…
Perceived organizational climate and turnover intention among young nurses from a humanistic care perspective: the mediating role of work engagement
BackgroundThe high turnover of young nurses poses a significant challenge to the stability of healthcare systems worldwide. While the relationships between perceived organizational climate, work engagement, and turnover intention are established, there is a lack of research integrating a humanistic…