News Feed
Is the oxytocin system a keystone in human wellbeing?
It has also taken over a century for science to fully realize that oxytocin is far more than a “female reproductive hormone.” Both the measurement and interpretation of the biochemical and functional properties of…
Asymmetric encoder-decoder U-net with hybrid attention and residual dilated convolution for brain tumor segmentation
InroductionThe accurate and automatic segmentation of brain tumors from magnetic resonance imaging is regarded as essential for clinical diagnosis and surgical planning. Nevertheless, the concurrent extraction of both local fine details and global contextual…
News
3048 results
Author Correction: Sex-specific biological aging clocks across organs and omics
Nature Medicine, Published online: 26 October 2026; doi:10.1038/s41591-026-04776-xAuthor Correction: Sex-specific biological aging clocks across organs and omics
Publisher Correction: Phenomic profiles and disease patterns of 1.9 million participants from Our Future Health
Nature Medicine, Published online: 26 October 2026; doi:10.1038/s41591-026-04774-zPublisher Correction: Phenomic profiles and disease patterns of 1.9 million participants from Our Future Health
Relatlimab plus nivolumab versus nivolumab for advanced melanoma: 5-year survival and biomarker analyses of the phase 3 RELATIVITY-047 trial
Nature Medicine, Published online: 24 October 2026; doi:10.1038/s41591-026-04756-1As presented at the ESMO Congress 2026: In a 5 year follow-up of survival and correlative data from the pivotal phase 3 RELATIVITY-047 trial comparing relatlimab plus nivolumab versus nivolumab alone in patients…
The Download: testing six tech promises and biotech’s blind spots
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Are we there yet? A reality check on six big tech promises Some seemingly impossible feats…
In the biotech world, you can’t see everything
Earlier this week, I attended a screening of You Can See Everything, the buzzy new documentary about the disgraced former biotech CEO Elizabeth Holmes. I went in not really knowing what to expect. I’d avoided spoilers (and won’t be giving…
Neural Mechanisms of Real-world Emotions and Internalizing
Conditions: Major Depression; Generalized Anxiety; Emotions Interventions: Behavioral: Academic Performance Feedback Sponsors: University of Miami; National Institute of Mental Health (NIMH) Recruiting
A Randomized, Open-Label, 52-Week Extension Study to Evaluate the Maintenance of Remission, Relapse Prevention, and Long-Term Safety of CreNeuroS™ in Patients With Major Depressive Disorder Who Achieved Remission Following an 8-Week Parent Study
Conditions: Adjunct in the Treatment of Depressive Disorder Interventions: Other: No intervention; Dietary Supplement: CreNeuroS™ CNS Fish Oil Plus Softgels, 1 capsule orally once daily; Dietary Supplement: CreNeuroS™ CNS Fish Oil Plus Softgels, 2 capsule orally once daily Sponsors: Sichuan…
A Clinical Trial to Evaluate the Efficacy and Safety of Meltz, a Digital Therapeutic Device, for Improving Panic Symptoms in Patients With Panic Disorder
Conditions: Panic Disorder; Agoraphobia Interventions: Device: Meltz; Device: Sham Application Sponsors: AIMNEXT; Korea University Anam Hospital; Kangbuk Samsung Hospital; National Traffic Injury Rehabilitation Hospital; CHA University Not yet recruiting
Sustained antidepressant-like effects of psychedelics through 5-HT2AR–β-arrestin signaling
Nature Neuroscience, Published online: 23 October 2026; doi:10.1038/s41593-026-02497-5This study shows that the sustained antidepressant-like effect of psychedelics is driven by 5-HT2A receptor–β-arrestin signaling. Repeated low-dose LSD preserves this effect in mice without inducing hallucinogenic-like behaviors in mice or monkeys.
Identification of candidate markers for the isolation of neuron-specific extracellular vesicles
Nature Neuroscience, Published online: 23 October 2026; doi:10.1038/s41593-026-02466-yThe authors developed methods to identify extracellular vesicles (EVs) in the blood that come from the brain by capturing EV surface proteins. This could be used in the future to diagnose neurological diseases.
Meta Mesh Ontology for Cross-Domain Mental Health Knowledge Integration: Development and Evaluation Study
Background: Psychiatric diagnostic practice faces persistent challenges in adequately capturing the complexity, heterogeneity, and dynamic nature of mental disorders. Conventional categorical classification systems such as the and the rely on rigid symptom-based criteria that often fail to represent multifactorial etiologies,…
Positive–affective and negative–cognitive brain–behavior axes in clinical high risk for psychosis
Individuals at clinical high risk for psychosis (CHR) present with heterogeneous combinations of positive, negative, and affective symptoms, cognitive difficulties, and functional impairment. However, reproducible multivariate links between this multidomain phenotype and brain morphology remain limited. This study explored the…
Human-in-the-Loop Suicide Risk Detection and Clinical Escalation in a Generative AI Mental Health Chatbot: Prospective Implementation Study
Background: Mental illness is a leading cause of disability worldwide, affecting more than 1 billion people, and suicide accounts for 720,000-800,000 deaths annually. Although AI-native mental health chatbots have the potential to help address the substantial gap between treatment needs…
What Living With OCD Really Feels Like
“I view having OCD like living inside a glass box while holding the keys to the door.” Adolfo Flores-Quilcate shares what rumination, diagnosis, and ERP have taught him — and why he believes healing is possible. The post What Living…
BAK and BAX form a multiprotein complex to drive mtDNA efflux and caspase-independent cell death
Science, Volume 394, Issue 6822, October 2026.
Wireless electrocatalytic closed-loop system for drug-free management of diabesity
Science, Volume 394, Issue 6822, October 2026.
Thermodynamic origin of the phonon Hall effect in a honeycomb antiferromagnet
Science, Volume 394, Issue 6822, Page 419-422, October 2026.
The microscope and the metaphor
Science, Volume 394, Issue 6822, Page 386-387, October 2026.
Temporal Interference Stimulation (TI) for Schizophrenia (SCZ)
Conditions: Schizophrenia Interventions: Device: Active transcranial temporal interference stimulation; Device: Sham transcranial temporal interference stimulation Sponsors: Anhui Medical University Not yet recruiting
News Feed
Is the oxytocin system a keystone in human wellbeing?
It has also taken over a century for science to fully realize that oxytocin is far more than a “female reproductive hormone.” Both the measurement and interpretation of the biochemical and functional properties of…
Asymmetric encoder-decoder U-net with hybrid attention and residual dilated convolution for brain tumor segmentation
InroductionThe accurate and automatic segmentation of brain tumors from magnetic resonance imaging is regarded as essential for clinical diagnosis and surgical planning. Nevertheless, the concurrent extraction of both local fine details and global contextual…
News
3048 results
Author Correction: Sex-specific biological aging clocks across organs and omics
Nature Medicine, Published online: 26 October 2026; doi:10.1038/s41591-026-04776-xAuthor Correction: Sex-specific biological aging clocks across organs and omics
Publisher Correction: Phenomic profiles and disease patterns of 1.9 million participants from Our Future Health
Nature Medicine, Published online: 26 October 2026; doi:10.1038/s41591-026-04774-zPublisher Correction: Phenomic profiles and disease patterns of 1.9 million participants from Our Future Health
Relatlimab plus nivolumab versus nivolumab for advanced melanoma: 5-year survival and biomarker analyses of the phase 3 RELATIVITY-047 trial
Nature Medicine, Published online: 24 October 2026; doi:10.1038/s41591-026-04756-1As presented at the ESMO Congress 2026: In a 5 year follow-up of survival and correlative data from the pivotal phase 3 RELATIVITY-047 trial comparing relatlimab plus nivolumab versus nivolumab alone in patients…
The Download: testing six tech promises and biotech’s blind spots
This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Are we there yet? A reality check on six big tech promises Some seemingly impossible feats…
In the biotech world, you can’t see everything
Earlier this week, I attended a screening of You Can See Everything, the buzzy new documentary about the disgraced former biotech CEO Elizabeth Holmes. I went in not really knowing what to expect. I’d avoided spoilers (and won’t be giving…
Neural Mechanisms of Real-world Emotions and Internalizing
Conditions: Major Depression; Generalized Anxiety; Emotions Interventions: Behavioral: Academic Performance Feedback Sponsors: University of Miami; National Institute of Mental Health (NIMH) Recruiting
A Randomized, Open-Label, 52-Week Extension Study to Evaluate the Maintenance of Remission, Relapse Prevention, and Long-Term Safety of CreNeuroS™ in Patients With Major Depressive Disorder Who Achieved Remission Following an 8-Week Parent Study
Conditions: Adjunct in the Treatment of Depressive Disorder Interventions: Other: No intervention; Dietary Supplement: CreNeuroS™ CNS Fish Oil Plus Softgels, 1 capsule orally once daily; Dietary Supplement: CreNeuroS™ CNS Fish Oil Plus Softgels, 2 capsule orally once daily Sponsors: Sichuan…
A Clinical Trial to Evaluate the Efficacy and Safety of Meltz, a Digital Therapeutic Device, for Improving Panic Symptoms in Patients With Panic Disorder
Conditions: Panic Disorder; Agoraphobia Interventions: Device: Meltz; Device: Sham Application Sponsors: AIMNEXT; Korea University Anam Hospital; Kangbuk Samsung Hospital; National Traffic Injury Rehabilitation Hospital; CHA University Not yet recruiting
Sustained antidepressant-like effects of psychedelics through 5-HT2AR–β-arrestin signaling
Nature Neuroscience, Published online: 23 October 2026; doi:10.1038/s41593-026-02497-5This study shows that the sustained antidepressant-like effect of psychedelics is driven by 5-HT2A receptor–β-arrestin signaling. Repeated low-dose LSD preserves this effect in mice without inducing hallucinogenic-like behaviors in mice or monkeys.
Identification of candidate markers for the isolation of neuron-specific extracellular vesicles
Nature Neuroscience, Published online: 23 October 2026; doi:10.1038/s41593-026-02466-yThe authors developed methods to identify extracellular vesicles (EVs) in the blood that come from the brain by capturing EV surface proteins. This could be used in the future to diagnose neurological diseases.
Meta Mesh Ontology for Cross-Domain Mental Health Knowledge Integration: Development and Evaluation Study
Background: Psychiatric diagnostic practice faces persistent challenges in adequately capturing the complexity, heterogeneity, and dynamic nature of mental disorders. Conventional categorical classification systems such as the and the rely on rigid symptom-based criteria that often fail to represent multifactorial etiologies,…
Positive–affective and negative–cognitive brain–behavior axes in clinical high risk for psychosis
Individuals at clinical high risk for psychosis (CHR) present with heterogeneous combinations of positive, negative, and affective symptoms, cognitive difficulties, and functional impairment. However, reproducible multivariate links between this multidomain phenotype and brain morphology remain limited. This study explored the…
Human-in-the-Loop Suicide Risk Detection and Clinical Escalation in a Generative AI Mental Health Chatbot: Prospective Implementation Study
Background: Mental illness is a leading cause of disability worldwide, affecting more than 1 billion people, and suicide accounts for 720,000-800,000 deaths annually. Although AI-native mental health chatbots have the potential to help address the substantial gap between treatment needs…
What Living With OCD Really Feels Like
“I view having OCD like living inside a glass box while holding the keys to the door.” Adolfo Flores-Quilcate shares what rumination, diagnosis, and ERP have taught him — and why he believes healing is possible. The post What Living…
BAK and BAX form a multiprotein complex to drive mtDNA efflux and caspase-independent cell death
Science, Volume 394, Issue 6822, October 2026.
Wireless electrocatalytic closed-loop system for drug-free management of diabesity
Science, Volume 394, Issue 6822, October 2026.
Thermodynamic origin of the phonon Hall effect in a honeycomb antiferromagnet
Science, Volume 394, Issue 6822, Page 419-422, October 2026.
The microscope and the metaphor
Science, Volume 394, Issue 6822, Page 386-387, October 2026.
Temporal Interference Stimulation (TI) for Schizophrenia (SCZ)
Conditions: Schizophrenia Interventions: Device: Active transcranial temporal interference stimulation; Device: Sham transcranial temporal interference stimulation Sponsors: Anhui Medical University Not yet recruiting