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Long-Read DNA Test Could Replace 15 Existing Tests for Rare Diseases
A DNA test for rare diseases using long-read sequencing can provide much more comprehensive results than standard diagnostics in a shorter amount of time. The post Long-Read DNA Test Could Replace 15 Existing Tests…
Maternal Blood Test Allows Comprehensive Genetic Fetal Screening
Non-invasive fetal sequencing (NIFS), a test developed by scientists at Harvard University, allows comprehensive genetic screening of a fetus using only a blood test from the expectant mother. The post Maternal Blood Test Allows…
Breaking Barriers in Student Mental Health Care With AI-Enhanced Group Cognitive Behavioral Therapy: Pilot Feasibility Study
Background: University students experience elevated psychological distress, with limited access to mental health services. While cognitive behavioral therapy (CBT) demonstrates efficacy for anxiety and depression, treatment gaps persist due to access barriers and insufficient…
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Acupuncture modulates the microbiota-gut-brain axis to treat irritable bowel syndrome: a mechanistic exploration
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder involving dysregulation of the microbiota-gut-brain (MGB) axis. Acupuncture effectively alleviates IBS symptoms, yet its underlying mechanisms remain incompletely understood. This review synthesizes current evidence to propose a mechanistic framework by…
A high-dimensional atlas of parvalbumin interneuron soma morphology in mouse visual and somatosensory cortex
Parvalbumin-positive (PV+) inhibitory interneurons are central components of experience-dependent plasticity in the visual cortex (V1). Anatomically, they are distributed across cortical layers and are traditionally classified as basket, chandelier, or bipolar cells based on dendritic and axonal arborization patterns. In…
Case Report: Reintroduction of winged infusion sets to needle syringe programs – advancing equity in harm reduction
BackgroundIn January 2023, following a 20-year ban, the New South Wales (NSW) Needle and Syringe Program (NSP) Guidelines permitted NSPs to provide winged infusion sets (‘butterflies’) and larger-volume syringes (‘barrels’) commonly used for injecting methadone liquid intravenously.ApproachThe Kirketon Road Centre…
Longitudinal changes in MMN and P3 during emotional processing in adolescents who engage in NSSI: a 12-week follow-up study
BackgroundAdolescents with nonsuicidal self-injury (NSSI) often show deficits in negative emotion regulation. Within the dual-process framework of implicit and explicit emotion regulation, these deficits may reflect an automatic bias toward negative information and insufficient later-stage controlled regulation. Whether routine clinical…
Tracking the longitudinal course of physiologic and mental health functioning among individuals in substance use disorder treatment
IntroductionMental health monitoring is crucial to long-term recovery in substance use disorder (SUD) treatment; however, little is known about how changes in physiological indicators align with changes in self-reported mental health over time.MethodsWe examined longitudinal associations of resting heart rate…
Association between plasma proBDNF levels and cognitive impairment in patients with alcohol dependence: a case–control and longitudinal study
BackgroundAlcohol dependence is frequently accompanied by cognitive impairment. Brain-derived neurotrophic factor (BDNF) signaling plays a critical role in synaptic plasticity, while the precursor form, proBDNF, has been increasingly implicated in neurodegenerative and psychiatric disorders. However, the association between plasma proBDNF…
The therapeutic role of self-transcendence in moral injury recovery: theory, mechanisms, and clinical implications
A growing body of psychological and neuroscientific research suggests that moral injury (MI) involves maladaptive self-referential processing, including disruptions in moral identity, rigid negative self-appraisals, and impaired meaning-making following exposure to potentially morally injurious events (PMIEs). Building on Mindfulness-to-Meaning Theory…
Brain Health for Economic Resilience: a data-driven framework for the brain-positive economic transition
Nature Medicine, Published online: 10 June 2026; doi:10.1038/s41591-026-04444-0Announced in this Comment and in collaboration with Nature Medicine is the convening of the Brain Health for Economic Resilience Commission, a global, transdisciplinary effort to define, measure and operationalize brain health and…
Dual-target gene therapy in Parkinson’s disease: a multicenter phase 1 trial
Nature Medicine, Published online: 10 June 2026; doi:10.1038/s41591-026-04436-0Phase 1 results reveal that BBM-P002, a dual-target gene therapy co-delivering TH and DDC, is safe and well tolerated in Parkinson’s disease, with 12-month motor improvements signaling therapeutic potential.
Cerebrovascular vulnerability and fibrosis in human brain aneurysms
Nature Neuroscience, Published online: 10 June 2026; doi:10.1038/s41593-026-02326-9A cell and spatial atlas of human brain aneurysms identifies an interaction between scarring fibroblasts and inflammatory macrophages linked to vessel wall remodeling, disease progression and rupture leading to stroke.
Cerebellar aging is spatially heterogeneous and supports cognitive resilience in later life
Nature Neuroscience, Published online: 10 June 2026; doi:10.1038/s41593-026-02289-xThe cerebellum ages unevenly, with some regions showing preservation that may help protect the brain from decline. The authors show that large cerebellar volume is associated with stronger cognitive resilience in healthy aging…
Triple-N dataset: large-scale fMRI-guided dense recordings of nonhuman primate neural responses to natural scenes
Nature Neuroscience, Published online: 10 June 2026; doi:10.1038/s41593-026-02322-zLi et al. used functional MRI-guided high-density electrophysiological recordings across macaque visual cortex to characterize responses to natural scenes, providing a resource for studying visual coding and cross-species comparisons.
DOJ reaches second settlement on youth gender care
A new era of American sunscreen, NIAID taps new acting director, and more health news from Morning Rounds
The “steroid olympics” were a circus—and a window into our culture
Testosterone. Methenolone. Nandrolone. Human growth hormone and EPO. Meldonium, modafinil, and mixed amphetamine salts. Clomiphene, anastrozole, levothyroxine, and liothyronine. Patches and capsules, creams and pills. A whole galaxy of steroids, metabolic modulators, and synthetic hormones coursing through the blood of a…
Are Republicans turning against medications for treating opioid addiction?
Federal actions and proposals have reignited debate over methadone and buprenorphine, worrying addiction experts and patient groups.
STAT+: As the U.S. looks on, European countries feel growing pressure on drug prices
In Europe, two divergent paths are emerging as countries grapple with what to do about drug prices, affecting both pharma and patients — and testing the influence of the U.S.
Opinion: Even in abortion-protecting states, teens face unnecessary barriers to care
“Legal protection for abortion does not mean equitable access for minors,” a pediatrics resident writes.
Opinion: ‘They all think I’m insane’: What it’s like to start medical residency at 72
“I know what I’m getting into”: Dawn Zuidgeest-Craft on starting medical residency at almost 73.
Feasibility Study of UP-A-AST Parent Group for Adolescents With Autism and Co-occurring Anxiety/Depression
Conditions: Autistic Spectrum Disorder; Anxiety Disorders; Depressive Disorder Interventions: Other: Unified Protocol-Adolescent Autism Parent Group (UP-A-AST) Sponsors: Sahlgrenska University Hospital Recruiting
The Role of Gender in Borderline Personality Disorder
Conditions: Borderline Personality Disorder (BPD) Sponsors: University Hospital Heidelberg Recruiting